Reactome | RYK binds WNT5A and VANGL2

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RYK binds WNT5A and VANGL2 Show undefined attributes

authored	[InstanceEdit:4549408] Rothfels, K, 2013-09-05
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:4551556] Rothfels, K, 2013-09-13
dbId	4551555
displayName	RYK binds WNT5A and VANGL2
edited	[InstanceEdit:4663813] Matthews, L, 2013-10-07
eventOf	[Pathway:R-HSA-4086400] PCP/CE pathway - Homo sapiens
inferredFrom	[Reaction:R-NUL-4551554] Wnt5a binds RYK and VANGL2 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-3247777] N4GlycoAsn-PalmS WNT5A(36-380) [extracellular region] [EntityWithAccessionedSequence:R-HSA-3006746] RYK [plasma membrane] [EntityWithAccessionedSequence:R-HSA-3965373] VANGL2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:4549501] The Wnt receptor Ryk plays a role in mammalian planar cell polarity signaling [LiteratureReference:4549496] The Wnt coreceptor Ryk regulates Wnt/planar cell polarity by modulating the degradation of the core planar cell polarity component Vangl2 [LiteratureReference:4549494] Ryks: new partners for Wnts in the developing and regenerating nervous system [LiteratureReference:4549492] Ryk: a novel Wnt receptor regulating axon pathfinding [LiteratureReference:4549498] The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum [LiteratureReference:4549491] Ryk-mediated Wnt repulsion regulates posterior-directed growth of corticospinal tract [LiteratureReference:5099842] Wnt-Ryk signalling mediates medial-lateral retinotectal topographic mapping
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RYK binds WNT5A and VANGL2
output	[Complex:R-HSA-4551548] N4GlycoAsn-PalmS-WNT5A:RYK:VANGL2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-3247843] secretion of WNT ligands - Homo sapiens
releaseDate	2013-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5099870] Kikuchi, Akira, 2013-11-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4551555
summation	[Summation:4551539] RYK is an atypical receptor tyrosine kinase-like receptor th...

Referrals

(hasEvent)	[Pathway:R-HSA-4086400] PCP/CE pathway
(inferredTo)	[Reaction:R-NUL-4551554] Wnt5a binds RYK and VANGL2