Reactome | VANGL2 is phosphorylated in response to WNT5A

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VANGL2 is phosphorylated in response to WNT5A Show undefined attributes

authored	[InstanceEdit:4549500] Rothfels, K, 2013-09-12
catalystActivity	[CatalystActivity:5250906] protein serine/threonine kinase activity of unknown kinase [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:4551569] Rothfels, K, 2013-09-13
dbId	4551570
displayName	VANGL2 is phosphorylated in response to WNT5A
edited	[InstanceEdit:4663813] Matthews, L, 2013-10-07
eventOf	[Pathway:R-HSA-4086400] PCP/CE pathway - Homo sapiens
inferredFrom	[Reaction:R-MMU-4551572] Vangl2 is phosphorylated in response to Wnt5a - Mus musculus
input	3 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-4551543] N4GlycoAsn-PalmS WNT5A:ROR2:VANGL2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:4551418] Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	VANGL2 is phosphorylated in response to WNT5A
output	3 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-4551546] N4GlycoAsn-PalmS WNT5A:ROR2:p-VANGL2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-4551571] WNT5A binds ROR2 and VANGL2 - Homo sapiens
releaseDate	2013-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5099870] Kikuchi, Akira, 2013-11-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4551570
summation	[Summation:4551472] Based on studies in mouse, human VANGL2 is predicted to be p...
updateTrackers	[UpdateTracker:9786794] Update Tracker - [Reaction:4551570] VANGL2 is phosphorylated in response to WNT5A - v48:[add_removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9786794] Update Tracker - [Reaction:4551570] VANGL2 is phosphorylated in response to WNT5A - v48:[add_removeCatalystActivity]
(hasEvent)	[Pathway:R-HSA-4086400] PCP/CE pathway
(inferredTo)	[Reaction:R-MMU-4551572] Vangl2 is phosphorylated in response to Wnt5a

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