Reactome | WNT5A-dependent internalization of FZD2, FZD5 and ROR2

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WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Show undefined attributes

authored	[InstanceEdit:5099870] Kikuchi, Akira, 2013-11-12
compartment	[Compartment:876] plasma membrane [Compartment:20592] clathrin-coated endocytic vesicle [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:5140746] Rothfels, K, 2013-11-15
dbId	5140745
displayName	WNT5A-dependent internalization of FZD2, FZD5 and ROR2
edited	[InstanceEdit:5144530] Matthews, L, 2013-11-15
eventOf	[Pathway:R-HSA-4086400] PCP/CE pathway - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5140741] WNT5A binds FZD and ROR receptors - Homo sapiens [BlackBoxEvent:R-HSA-5140747] FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5140717] An anti-Wnt5a antibody suppresses metastasis of gastric cancer cells in vivo by inhibiting receptor-mediated endocytosis [LiteratureReference:5140719] Laminin gamma2 mediates Wnt5a-induced invasion of gastric cancer cells [LiteratureReference:5140720] Wnt5a regulates distinct signalling pathways by binding to Frizzled2 [LiteratureReference:3238088] Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	WNT5A-dependent internalization of FZD2, FZD5 and ROR2
orthologousEvent	[Pathway:R-CEL-5140745] WNT5A-dependent internalization of FZD2, FZD5 and ROR2 - Caenorhabditis elegans [Pathway:R-DME-5140745] WNT5A-dependent internalization of FZD2, FZD5 and ROR2 - Drosophila melanogaster [Pathway:R-GGA-5140745] WNT5A-dependent internalization of FZD2, FZD5 and ROR2 - Gallus gallus [Pathway:R-XTR-5140745] WNT5A-dependent internalization of FZD2, FZD5 and ROR2 - Xenopus tropicalis [Pathway:R-DRE-5140745] WNT5A-dependent internalization of FZD2, FZD5 and ROR2 - Danio rerio [Pathway:R-SSC-5140745] WNT5A-dependent internalization of FZD2, FZD5 and ROR2 - Sus scrofa [Pathway:R-BTA-5140745] WNT5A-dependent internalization of FZD2, FZD5 and ROR2 - Bos taurus [Pathway:R-CFA-5140745] WNT5A-dependent internalization of FZD2, FZD5 and ROR2 - Canis familiaris [Pathway:R-RNO-5140745] WNT5A-dependent internalization of FZD2, FZD5 and ROR2 - Rattus norvegicus [Pathway:R-MMU-5140745] WNT5A-dependent internalization of FZD2, FZD5 and ROR2 - Mus musculus
releaseDate	2013-12-04
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5140745
summation	[Summation:5140734] Internalization of FZD2, FZD5 and ROR2 after WNT5A binding i...

Referrals

(hasEvent)

[Pathway:R-HSA-4086400] PCP/CE pathway