Reactome | SUMOylation of transcription cofactors

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SUMOylation of transcription cofactors Show undefined attributes

authored	[InstanceEdit:3826675] May, B, 2013-07-08
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3899303] May, B, 2013-07-12
dbId	3899300
displayName	SUMOylation of transcription cofactors
doi	10.3180/R-HSA-3899300.4
edited	[InstanceEdit:3826675] May, B, 2013-07-08
eventOf	[Pathway:R-HSA-3108232] SUMO E3 ligases SUMOylate target proteins - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-5228521] PIAS1,4 SUMOylate CASP8AP2 with SUMO1 - Homo sapiens [Reaction:R-HSA-3927824] PRC1 SUMOylates CASP8AP2 with SUMO1 - Homo sapiens [Reaction:R-HSA-3927959] SUMOylation of CREBBP with SUMO1 - Homo sapiens [Reaction:R-HSA-3108209] PRC1 SUMOylates CTBP1 with SUMO1 - Homo sapiens [Reaction:R-HSA-3108203] PRC1 SUMOylates CTBP1 with SUMO2,3 - Homo sapiens [Reaction:R-HSA-4085992] SUMOylation of DAXX with SUMO1 - Homo sapiens [Reaction:R-HSA-3900177] SUMOylation of DDX5 with SUMO1 - Homo sapiens [Reaction:R-HSA-3900194] PIAS1 SUMOylates DDX5 with SUMO2 - Homo sapiens [Reaction:R-HSA-3900047] SUMOylation of DDX17 with SUMO1 - Homo sapiens [Reaction:R-HSA-3899291] SUMOylation of EP300 with SUMO1 - Homo sapiens [Reaction:R-HSA-4090284] SUMOylation of HIPK2 with SUMO1 - Homo sapiens [Reaction:R-HSA-4086083] SUMOylation of ING2 with SUMO1 - Homo sapiens [Reaction:R-HSA-4090288] PIAS1,3 SUMOylate MBD1 with SUMO1 - Homo sapiens [Reaction:R-HSA-3900070] SUMOylation of MKL1 with SUMO1 - Homo sapiens [Reaction:R-HSA-3927886] SUMOylation of NCOR2 with SUMO1 - Homo sapiens [Reaction:R-HSA-4085296] SUMOylation of NCOA1 with SUMO1 - Homo sapiens [Reaction:R-HSA-4085318] SUMOylation of NCOA2 with SUMO1 - Homo sapiens [Reaction:R-HSA-4086088] SUMOylation of NPM1 with SUMO1 - Homo sapiens [Reaction:R-HSA-4086059] SUMOylation of NPM1 with SUMO2,3 - Homo sapiens [Reaction:R-HSA-4086036] PIAS1,3 SUMOylate NRIP1 with SUMO1 - Homo sapiens [Reaction:R-HSA-4085331] PIAS2-1 SUMOylates PARK7 with SUMO1 - Homo sapiens [Reaction:R-HSA-3903017] SUMOylation of PPARGC1A with SUMO1 - Homo sapiens [Reaction:R-HSA-4085347] PIAS1 SUMOylates SAFB with SUMO1 - Homo sapiens [Reaction:R-HSA-4085372] PIAS1 SUMOylates SAFB with SUMO2,3 - Homo sapiens [Reaction:R-HSA-4085994] TOPORS SUMOylates SIN3A with SUMO1 - Homo sapiens [Reaction:R-HSA-3782535] TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1 - Homo sapiens [Reaction:R-HSA-3296126] CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-04-07
literatureReference	[LiteratureReference:4663804] A role for SUMO modification in transcriptional repression and activation [LiteratureReference:4663799] SUMO and transcriptional regulation [LiteratureReference:4686128] SUMO association with repressor complexes, emerging routes for transcriptional control [LiteratureReference:4663806] Something about SUMO inhibits transcription
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	SUMOylation of transcription cofactors
orthologousEvent	[Pathway:R-MMU-3899300] SUMOylation of transcription cofactors - Mus musculus [Pathway:R-RNO-3899300] SUMOylation of transcription cofactors - Rattus norvegicus [Pathway:R-BTA-3899300] SUMOylation of transcription cofactors - Bos taurus [Pathway:R-SSC-3899300] SUMOylation of transcription cofactors - Sus scrofa [Pathway:R-DRE-3899300] SUMOylation of transcription cofactors - Danio rerio [Pathway:R-XTR-3899300] SUMOylation of transcription cofactors - Xenopus tropicalis [Pathway:R-GGA-3899300] SUMOylation of transcription cofactors - Gallus gallus [Pathway:R-DME-3899300] SUMOylation of transcription cofactors - Drosophila melanogaster [Pathway:R-CEL-3899300] SUMOylation of transcription cofactors - Caenorhabditis elegans [Pathway:R-DDI-3899300] SUMOylation of transcription cofactors - Dictyostelium discoideum [Pathway:R-SPO-3899300] SUMOylation of transcription cofactors - Schizosaccharomyces pombe [Pathway:R-SCE-3899300] SUMOylation of transcription cofactors - Saccharomyces cerevisiae [Pathway:R-PFA-3899300] SUMOylation of transcription cofactors - Plasmodium falciparum
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8955405] Fuller-Pace, Frances V, 2017-01-11 [InstanceEdit:9608076] Niskanen, Einari, 2018-05-09 [InstanceEdit:9615865] Niskanen, Einari, 2018-08-08
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-3899300
summation	[Summation:5225573] SUMO1,2, and 3 are predominantly located in the nucleus and ...
updateTrackers	[UpdateTracker:9779452] Update Tracker - [Pathway:3899300] SUMOylation of transcription cofactors - v65:[addHasEvent] [UpdateTracker:9864311] Update Tracker - [Pathway:3899300] SUMOylation of transcription cofactors - v88:[updateContainedRLE] [UpdateTracker:9774946] Update Tracker - [Pathway:3899300] SUMOylation of transcription cofactors - v80:[updateContainedRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-3108232] SUMO E3 ligases SUMOylate target proteins
(updatedInstance)	[UpdateTracker:9779452] Update Tracker - [Pathway:3899300] SUMOylation of transcription cofactors - v65:[addHasEvent] [UpdateTracker:9864311] Update Tracker - [Pathway:3899300] SUMOylation of transcription cofactors - v88:[updateContainedRLE] [UpdateTracker:9774946] Update Tracker - [Pathway:3899300] SUMOylation of transcription cofactors - v80:[updateContainedRLE]

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