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Entries
TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1
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authored
[InstanceEdit:3782612] May, B, 2013-06-30
catalystActivity
[CatalystActivity:4090335] SUMO transferase activity of TRIM28 [nucleoplasm]
catalystActivityReference
[CatalystActivityReference:9643106] SUMO transferase activity of TRIM28 [nucleoplasm] Sumoylation of the transcriptional intermediary factor 1beta (TIF1beta), the Co-repressor of the KRAB Multifinger proteins, is required for its transcriptional activity and is modulated by the KRAB domain
category
transition
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:3782606] May, B, 2013-06-30
dbId
3782535
displayName
TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1
edited
[InstanceEdit:3782612] May, B, 2013-06-30
eventOf
[Pathway:R-HSA-3899300] SUMOylation of transcription cofactors - Homo sapiens
input
6 ×
[Complex:R-HSA-2993783] SUMO1:C93-UBE2I [nucleoplasm]
[Complex:R-HSA-3782565] TRIM28:ZNF350 [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:3782593] Doxorubicin down-regulates Kruppel-associated box domain-associated protein 1 sumoylation that relieves its transcription repression on p21WAF1/CIP1 in breast cancer MCF-7 cells
[LiteratureReference:3782594] Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression
[LiteratureReference:1220630] PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing
[LiteratureReference:1220623] Structural insights into human KAP1 PHD finger-bromodomain and its role in gene silencing
[LiteratureReference:4090300] Sumoylation of the transcriptional intermediary factor 1beta (TIF1beta), the Co-repressor of the KRAB Multifinger proteins, is required for its transcriptional activity and is modulated by the KRAB domain
[LiteratureReference:5626900] Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli
maxDepth
1
modified
[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name
TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1
orthologousEvent
[Reaction:R-GGA-3782535] TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1 - Gallus gallus
[Reaction:R-DRE-3782535] TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1 - Danio rerio
[Reaction:R-SSC-3782535] TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1 - Sus scrofa
[Reaction:R-BTA-3782535] TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1 - Bos taurus
[Reaction:R-RNO-3782535] TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1 - Rattus norvegicus
output
[Complex:R-HSA-3782577] monoSUMO1-TRIM28:ZNF350 [nucleoplasm]
6 ×
[EntityWithAccessionedSequence:R-HSA-912481] UBE2I [nucleoplasm]
precedingEvent
[Reaction:R-HSA-2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9) - Homo sapiens
releaseDate
2018-06-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9608076] Niskanen, Einari, 2018-05-09
[InstanceEdit:9615865] Niskanen, Einari, 2018-08-08
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-3782535
summation
[Summation:3782564] The PHD domain of TRIM28 (KAP1) acts as a SUMO E3 ligase to ...
Referrals
(hasEvent)
[Pathway:R-HSA-3899300] SUMOylation of transcription cofactors
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