Reactome | PIAS2-1 SUMOylates PARK7 with SUMO1

Schema > Reaction > Entries

PIAS2-1 SUMOylates PARK7 with SUMO1 Show undefined attributes

authored	[InstanceEdit:4085323] May, B, 2013-08-03
catalystActivity	[CatalystActivity:3246003] SUMO transferase activity of PIAS2-1 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643502] SUMO transferase activity of PIAS2-1 [nucleoplasm] SUMOylation of GTF2IRD1 regulates protein partner interactions and ubiquitin-mediated degradation
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4085367] May, B, 2013-08-05
dbId	4085331
displayName	PIAS2-1 SUMOylates PARK7 with SUMO1
edited	[InstanceEdit:4085323] May, B, 2013-08-03
eventOf	[Pathway:R-HSA-3899300] SUMOylation of transcription cofactors - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-3900141] PARK7 [nucleoplasm] [Complex:R-HSA-2993783] SUMO1:C93-UBE2I [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4085374] DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor [LiteratureReference:4085353] Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities [LiteratureReference:8953815] Sumoylation is critical for DJ-1 to repress p53 transcriptional activity
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	PIAS2-1 SUMOylates PARK7 with SUMO1
orthologousEvent	[Reaction:R-SPO-4085331] PIAS2-1 SUMOylates PARK7 with SUMO1 - Schizosaccharomyces pombe [Reaction:R-CEL-4085331] PIAS2-1 SUMOylates PARK7 with SUMO1 - Caenorhabditis elegans [Reaction:R-GGA-4085331] PIAS2-1 SUMOylates PARK7 with SUMO1 - Gallus gallus [Reaction:R-SSC-4085331] PIAS2-1 SUMOylates PARK7 with SUMO1 - Sus scrofa [Reaction:R-BTA-4085331] PIAS2-1 SUMOylates PARK7 with SUMO1 - Bos taurus [Reaction:R-RNO-4085331] PIAS2-1 SUMOylates PARK7 with SUMO1 - Rattus norvegicus [Reaction:R-MMU-4085331] PIAS2-1 SUMOylates PARK7 with SUMO1 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-4085351] monoSUMO1-K130-PARK7 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-912481] UBE2I [nucleoplasm]
precedingEvent	[Reaction:R-HSA-2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9) - Homo sapiens
releaseDate	2018-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9608076] Niskanen, Einari, 2018-05-09 [InstanceEdit:9615865] Niskanen, Einari, 2018-08-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4085331
summation	[Summation:4085354] PIAS2-1 (PIASxalpha) SUMOylates PARK7 (DJ-1) at lysine-130 w...
updateTrackers	[UpdateTracker:9775243] Update Tracker - [Reaction:4085331] PIAS2-1 SUMOylates PARK7 with SUMO1 - v80:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9775243] Update Tracker - [Reaction:4085331] PIAS2-1 SUMOylates PARK7 with SUMO1 - v80:[add_removeOutput]
(hasEvent)	[Pathway:R-HSA-3899300] SUMOylation of transcription cofactors