Reactome | PIAS1,4 SUMOylate CASP8AP2 with SUMO1

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PIAS1,4 SUMOylate CASP8AP2 with SUMO1 Show undefined attributes

authored	[InstanceEdit:3903025] May, B, 2013-07-16
catalystActivity	[CatalystActivity:2997675] SUMO transferase activity of PIAS1,4 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5228504] May, B, 2014-01-13
dbId	5228521
displayName	PIAS1,4 SUMOylate CASP8AP2 with SUMO1
edited	[InstanceEdit:3903025] May, B, 2013-07-16
eventOf	[Pathway:R-HSA-3899300] SUMOylation of transcription cofactors - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-3927945] CASP8AP2 [nucleoplasm] [Complex:R-HSA-2993783] SUMO1:C93-UBE2I [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3927931] SUMO modification regulates the transcriptional activity of FLASH [LiteratureReference:3927949] PIAS1 interacts with FLASH and enhances its co-activation of c-Myb [LiteratureReference:8953827] SUMO regulates proteasome-dependent degradation of FLASH/Casp8AP2
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	PIAS1,4 SUMOylate CASP8AP2 with SUMO1 PIAS1,PIAS4 SUMOylate FLASH
orthologousEvent	[Reaction:R-GGA-5228521] PIAS1,4 SUMOylate CASP8AP2 with SUMO1 - Gallus gallus [Reaction:R-DRE-5228521] PIAS1,4 SUMOylate CASP8AP2 with SUMO1 - Danio rerio [Reaction:R-SSC-5228521] PIAS1,4 SUMOylate CASP8AP2 with SUMO1 - Sus scrofa [Reaction:R-BTA-5228521] PIAS1,4 SUMOylate CASP8AP2 with SUMO1 - Bos taurus [Reaction:R-RNO-5228521] PIAS1,4 SUMOylate CASP8AP2 with SUMO1 - Rattus norvegicus [Reaction:R-MMU-5228521] PIAS1,4 SUMOylate CASP8AP2 with SUMO1 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-3927850] monoSUMO1-K1813-CASP8AP2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-912481] UBE2I [nucleoplasm]
precedingEvent	[Reaction:R-HSA-2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9) - Homo sapiens
releaseDate	2018-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9608076] Niskanen, Einari, 2018-05-09 [InstanceEdit:9615865] Niskanen, Einari, 2018-08-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5228521
summation	[Summation:3927831] PIAS1, PIAS4 SUMOylate CASP8AP2 (FLASH) at lysine-1813 with ...
updateTrackers	[UpdateTracker:9775051] Update Tracker - [Reaction:5228521] PIAS1,4 SUMOylate CASP8AP2 with SUMO1 - v80:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9775051] Update Tracker - [Reaction:5228521] PIAS1,4 SUMOylate CASP8AP2 with SUMO1 - v80:[add_removeOutput]
(hasEvent)	[Pathway:R-HSA-3899300] SUMOylation of transcription cofactors

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