Reactome | CBX4, UHRF2 SUMOylate ZNF131 with SUMO1

Schema > Reaction > Entries

CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 Show undefined attributes

authored	[InstanceEdit:3296160] May, B, 2013-04-13
catalystActivity	[CatalystActivity:3296187] SUMO transferase activity of CBX4, UHRF2 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643834] SUMO transferase activity of CBX4, UHRF2 [nucleoplasm] Small ubiquitin-like modifier (SUMO) modification of zinc finger protein 131 potentiates its negative effect on estrogen signaling
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3296159] May, B, 2013-04-18
dbId	3296126
displayName	CBX4, UHRF2 SUMOylate ZNF131 with SUMO1
edited	[InstanceEdit:3296160] May, B, 2013-04-13
eventOf	[Pathway:R-HSA-3899300] SUMOylation of transcription cofactors - Homo sapiens
input	[Complex:R-HSA-2993783] SUMO1:C93-UBE2I [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-3296168] ZNF131 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3296151] Small ubiquitin-like modifier (SUMO) modification of zinc finger protein 131 potentiates its negative effect on estrogen signaling [LiteratureReference:3296184] UHRF2, a Ubiquitin E3 Ligase, Acts as a Small Ubiquitin-like Modifier E3 Ligase for Zinc Finger Protein 131
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	CBX4, UHRF2 SUMOylate ZNF131 with SUMO1
orthologousEvent	[Reaction:R-GGA-3296126] CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 - Gallus gallus [Reaction:R-DRE-3296126] CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 - Danio rerio [Reaction:R-BTA-3296126] CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 - Bos taurus [Reaction:R-RNO-3296126] CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 - Rattus norvegicus [Reaction:R-MMU-3296126] CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-3296152] monoSUMO1-K601-ZNF131 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-912481] UBE2I [nucleoplasm]
precedingEvent	[Reaction:R-HSA-2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9) - Homo sapiens
releaseDate	2018-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9608076] Niskanen, Einari, 2018-05-09 [InstanceEdit:9615865] Niskanen, Einari, 2018-08-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3296126
summation	[Summation:3296186] CBX4 (Pc2) and UHRF2 are able to SUMOylate ZNF131 on lysine-...
updateTrackers	[UpdateTracker:9775056] Update Tracker - [Reaction:3296126] CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 - v80:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9775056] Update Tracker - [Reaction:3296126] CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 - v80:[add_removeOutput]
(hasEvent)	[Pathway:R-HSA-3899300] SUMOylation of transcription cofactors