Reactome | SUMOylation of NPM1 with SUMO2,3

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SUMOylation of NPM1 with SUMO2,3 Show undefined attributes

authored	[InstanceEdit:4085380] May, B, 2013-08-05
catalystActivity	[CatalystActivity:3246099] SUMO transferase activity of UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4086035] May, B, 2013-08-06
dbId	4086059
displayName	SUMOylation of NPM1 with SUMO2,3
edited	[InstanceEdit:4085380] May, B, 2013-08-05
eventOf	[Pathway:R-HSA-3899300] SUMOylation of transcription cofactors - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-606320] NPM1 [nucleoplasm] 2 × [DefinedSet:R-HSA-3899312] UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4086007] Sumoylation of nucleophosmin/B23 regulates its subcellular localization, mediating cell proliferation and survival [LiteratureReference:3214945] Novel proteomics strategy brings insight into the prevalence of SUMO-2 target sites [LiteratureReference:5626896] Uncovering global SUMOylation signaling networks in a site-specific manner
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	SUMOylation of NPM1 with SUMO2,3
orthologousEvent	[Reaction:R-DME-4086059] SUMOylation of NPM1 with SUMO2,3 - Drosophila melanogaster [Reaction:R-GGA-4086059] SUMOylation of NPM1 with SUMO2,3 - Gallus gallus [Reaction:R-XTR-4086059] SUMOylation of NPM1 with SUMO2,3 - Xenopus tropicalis [Reaction:R-DRE-4086059] SUMOylation of NPM1 with SUMO2,3 - Danio rerio [Reaction:R-SSC-4086059] SUMOylation of NPM1 with SUMO2,3 - Sus scrofa [Reaction:R-BTA-4086059] SUMOylation of NPM1 with SUMO2,3 - Bos taurus [Reaction:R-RNO-4086059] SUMOylation of NPM1 with SUMO2,3 - Rattus norvegicus [Reaction:R-MMU-4086059] SUMOylation of NPM1 with SUMO2,3 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-4086056] polySUMO2,3-K263-NPM1 [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-HSA-912481] UBE2I [nucleoplasm]
precedingEvent	[Reaction:R-HSA-2993790] Transfer of SUMO2 from E1 to UBE2I (UBC9) - Homo sapiens [Reaction:R-HSA-2993769] Transfer of SUMO3 from E1 to UBE2I (UBC9) - Homo sapiens
releaseDate	2018-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9608076] Niskanen, Einari, 2018-05-09 [InstanceEdit:9615865] Niskanen, Einari, 2018-08-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4086059
summation	[Summation:4086065] NPM1 (Nucleophosmin, B23) is SUMOylated at lysine-263 with S...

Referrals

(hasEvent)

[Pathway:R-HSA-3899300] SUMOylation of transcription cofactors