Reactome | PIAS1 SUMOylates SAFB with SUMO2,3

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PIAS1 SUMOylates SAFB with SUMO2,3 Show undefined attributes

authored	[InstanceEdit:4085323] May, B, 2013-08-03
catalystActivity	[CatalystActivity:3247478] SUMO transferase activity of PIAS1 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643901] SUMO transferase activity of PIAS1 [nucleoplasm] Transcription factor Sp3 is silenced through SUMO modification by PIAS1
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4085367] May, B, 2013-08-05
dbId	4085372
displayName	PIAS1 SUMOylates SAFB with SUMO2,3
edited	[InstanceEdit:4085323] May, B, 2013-08-03
eventOf	[Pathway:R-HSA-3899300] SUMOylation of transcription cofactors - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-4085379] SAFB [nucleoplasm] 4 × [DefinedSet:R-HSA-3899312] UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4085338] Co-repressor activity of scaffold attachment factor B1 requires sumoylation
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	PIAS1 SUMOylates SAFB with SUMO2,3
orthologousEvent	[Reaction:R-DME-4085372] PIAS1 SUMOylates SAFB with SUMO2,3 - Drosophila melanogaster [Reaction:R-GGA-4085372] PIAS1 SUMOylates SAFB with SUMO2,3 - Gallus gallus [Reaction:R-DRE-4085372] PIAS1 SUMOylates SAFB with SUMO2,3 - Danio rerio [Reaction:R-SSC-4085372] PIAS1 SUMOylates SAFB with SUMO2,3 - Sus scrofa [Reaction:R-BTA-4085372] PIAS1 SUMOylates SAFB with SUMO2,3 - Bos taurus [Reaction:R-RNO-4085372] PIAS1 SUMOylates SAFB with SUMO2,3 - Rattus norvegicus [Reaction:R-MMU-4085372] PIAS1 SUMOylates SAFB with SUMO2,3 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-4085357] polySUMO2,3-K231,K294-SAFB [nucleoplasm] 4 × [EntityWithAccessionedSequence:R-HSA-912481] UBE2I [nucleoplasm]
precedingEvent	[Reaction:R-HSA-2993790] Transfer of SUMO2 from E1 to UBE2I (UBC9) - Homo sapiens [Reaction:R-HSA-2993769] Transfer of SUMO3 from E1 to UBE2I (UBC9) - Homo sapiens
releaseDate	2018-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9608076] Niskanen, Einari, 2018-05-09 [InstanceEdit:9615865] Niskanen, Einari, 2018-08-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4085372
summation	[Summation:4085376] PIAS1 SUMOylates SAFB at lysine 231 and lysine 294 with SUMO...

Referrals

(hasEvent)

[Pathway:R-HSA-3899300] SUMOylation of transcription cofactors