Reactome | PRC1 SUMOylates CASP8AP2 with SUMO1

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PRC1 SUMOylates CASP8AP2 with SUMO1 Show undefined attributes

authored	[InstanceEdit:3903025] May, B, 2013-07-16
catalystActivity	[CatalystActivity:3108185] SUMO transferase activity of PRC1 complex [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9644136] SUMO transferase activity of PRC1 complex [nucleoplasm] The polycomb protein Pc2 is a SUMO E3
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3927908] May, B, 2013-07-21
dbId	3927824
displayName	PRC1 SUMOylates CASP8AP2 with SUMO1
edited	[InstanceEdit:3903025] May, B, 2013-07-16
eventOf	[Pathway:R-HSA-3899300] SUMOylation of transcription cofactors - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-3927945] CASP8AP2 [nucleoplasm] [Complex:R-HSA-2993783] SUMO1:C93-UBE2I [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3927931] SUMO modification regulates the transcriptional activity of FLASH [LiteratureReference:8953827] SUMO regulates proteasome-dependent degradation of FLASH/Casp8AP2
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	PRC1 SUMOylates CASP8AP2 with SUMO1 Pc2 SUMOylates FLASH
orthologousEvent	[Reaction:R-GGA-3927824] PRC1 SUMOylates CASP8AP2 with SUMO1 - Gallus gallus [Reaction:R-DRE-3927824] PRC1 SUMOylates CASP8AP2 with SUMO1 - Danio rerio [Reaction:R-SSC-3927824] PRC1 SUMOylates CASP8AP2 with SUMO1 - Sus scrofa [Reaction:R-BTA-3927824] PRC1 SUMOylates CASP8AP2 with SUMO1 - Bos taurus [Reaction:R-RNO-3927824] PRC1 SUMOylates CASP8AP2 with SUMO1 - Rattus norvegicus [Reaction:R-MMU-3927824] PRC1 SUMOylates CASP8AP2 with SUMO1 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-3927850] monoSUMO1-K1813-CASP8AP2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-912481] UBE2I [nucleoplasm]
precedingEvent	[Reaction:R-HSA-2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9) - Homo sapiens
releaseDate	2018-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9608076] Niskanen, Einari, 2018-05-09 [InstanceEdit:9615865] Niskanen, Einari, 2018-08-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3927824
summation	[Summation:5228514] The CBX3 component of PRC1 SUMOylates CASP8AP2 (FLASH) at ly...
updateTrackers	[UpdateTracker:9774853] Update Tracker - [Reaction:3927824] PRC1 SUMOylates CASP8AP2 with SUMO1 - v80:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9774853] Update Tracker - [Reaction:3927824] PRC1 SUMOylates CASP8AP2 with SUMO1 - v80:[add_removeOutput]
(hasEvent)	[Pathway:R-HSA-3899300] SUMOylation of transcription cofactors

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