Reactome | Peptide ligand-binding receptors

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Peptide ligand-binding receptors Show undefined attributes

authored	[InstanceEdit:375275] Jassal, Bijay, 2008-08-21
created	[InstanceEdit:375275] Jassal, Bijay, 2008-08-21
dbId	375276
displayName	Peptide ligand-binding receptors
doi	10.3180/R-HSA-375276.9
edited	[InstanceEdit:375493] D'Eustachio, P, 2008-09-01 11:58:31
eventOf	[Pathway:R-HSA-373076] Class A/1 (Rhodopsin-like receptors) - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-374173] AGT(25-32) binds to AGTR1 - Homo sapiens [Reaction:R-HSA-9615348] AGT(25-32) binds to AGTR2 - Homo sapiens [Reaction:R-HSA-9615249] ARBs bind AGTR1 - Homo sapiens [Reaction:R-HSA-9944515] AGT(25-31) binds MAS1 - Homo sapiens [Reaction:R-HSA-9944544] Alamandine binds MRGPRD (MrgD) - Homo sapiens [Reaction:R-HSA-374337] Apelin receptor binds to apelin - Homo sapiens [Reaction:R-HSA-375384] Bombesin-like receptors bind bombesin homologues - Homo sapiens [Reaction:R-HSA-374331] Bradykinin receptors B1 and B2 bind to bradykinin - Homo sapiens [Reaction:R-HSA-964811] C5AR2 binds anaphylatoxins and thier desArginated derivatives - Homo sapiens [Reaction:R-HSA-375395] C5a receptor binds C5a anaphylatoxin - Homo sapiens [Reaction:R-HSA-444647] C3a receptor binds anaphylatoxin C3a - Homo sapiens [Reaction:R-HSA-374251] DARC is a non-specific receptor for many chemokines - Homo sapiens [Reaction:R-HSA-374207] G protein-coupled estrogen receptor 1 binds estrogen non-classically - Homo sapiens [Reaction:R-HSA-374787] GPCR neuropeptide receptor binds neuropeptides B and W - Homo sapiens [Reaction:R-HSA-374723] Nociceptin receptor binds to nociceptin - Homo sapiens [Reaction:R-HSA-374298] Opioid receptors bind opioid peptides - Homo sapiens [Pathway:R-HSA-380108] Chemokine receptors bind chemokines - Homo sapiens [Reaction:R-HSA-374758] Somatostatin receptors bind somatostatin and cortistatin - Homo sapiens [Pathway:R-HSA-380095] Tachykinin receptors bind tachykinins - Homo sapiens [Pathway:R-HSA-388479] Vasopressin-like receptors - Homo sapiens [Reaction:R-HSA-388529] Cholecystokinin receptors bind cholecystokinin - Homo sapiens [Reaction:R-HSA-8876868] ECE1 cleaves EDN1(53-90) - Homo sapiens [Reaction:R-HSA-8877620] ECE2 cleaves EDN1(53-90) - Homo sapiens [Reaction:R-HSA-5694082] XK:KEL:Zn2+ cleaves EDN3 - Homo sapiens [Reaction:R-HSA-388560] EDNRA,EDNRB bind EDNs - Homo sapiens [Reaction:R-HSA-9731924] EDNRA binds EDNs - Homo sapiens [Reaction:R-HSA-9731393] EDNRA, EDNRB bind non-selective ERAs - Homo sapiens [Reaction:R-HSA-9731931] EDNRA binds selective ERAs - Homo sapiens [Reaction:R-HSA-388596] Melanocortin receptors bind melanocortins - Homo sapiens [Reaction:R-HSA-388605] POMC(138-176) binds MC2R - Homo sapiens [Reaction:R-HSA-388855] Prolactin-releasing hormone receptor binds PRH - Homo sapiens [Reaction:R-HSA-388863] Neuropeptide Y receptors can bind neuropeptide Y-related peptides - Homo sapiens [Reaction:R-HSA-388900] Neurotensin receptors can bind neurotensins - Homo sapiens [Reaction:R-HSA-389026] Galanin receptors can bind galanin - Homo sapiens [Reaction:R-HSA-388981] The Kiss receptor GPR54 binds kisspeptin - Homo sapiens [Reaction:R-HSA-389463] Proteinase-activated receptors can bind thrombin - Homo sapiens [Pathway:R-HSA-389397] Orexin and neuropeptides FF and QRFP bind to their respective receptors - Homo sapiens [Reaction:R-HSA-444208] MLNR (GPR38) is a receptor for motilin - Homo sapiens [Pathway:R-HSA-444473] Formyl peptide receptors bind formyl peptides and many other ligands - Homo sapiens [Reaction:R-HSA-444498] Thyrotropin-releasing hormone receptor binds thyrotropin - Homo sapiens [Reaction:R-HSA-444620] Neuropeptide S receptor binds neuropeptide S - Homo sapiens [Reaction:R-HSA-444691] Prokineticin receptors bind prokineticin - Homo sapiens [Pathway:R-HSA-444821] Relaxin receptors - Homo sapiens [Reaction:R-HSA-445113] Urotensin-2 receptor binds urotensin-2 and 2B - Homo sapiens [Reaction:R-HSA-947647] GHSR is a receptor for ghrelin - Homo sapiens [Reaction:R-HSA-947673] Melanin-concentrating hormone receptors bind MCH - Homo sapiens [Reaction:R-HSA-964800] Neuromedin-U receptors bind neuromedins U, S - Homo sapiens [Reaction:R-HSA-981832] NMUR2 binds neuromedin-S - Homo sapiens [Reaction:R-HSA-5336182] GPR37 binds prosaptide - Homo sapiens [Reaction:R-HSA-5336184] GPR37L binds prosaposin - Homo sapiens [Reaction:R-HSA-8940959] Neurolysin degrades neurotensin - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-06-09
literatureReference	[LiteratureReference:373369] The role of chemokines and chemokine receptors in eosinophil activation during inflammatory allergic reactions [LiteratureReference:374230] International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences [LiteratureReference:374144] International union of pharmacology. XXIII. The angiotensin II receptors [LiteratureReference:374090] Signal transduction induced by opioids in immune cells: a review [LiteratureReference:375226] Somatostatin receptors [LiteratureReference:375245] Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system [LiteratureReference:375233] The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implications in health and disease [LiteratureReference:375232] BLT1 and BLT2: the leukotriene B(4) receptors [LiteratureReference:375225] Cysteinyl leukotriene receptors [LiteratureReference:375241] Relaxin family peptide receptors--former orphans reunite with their parent ligands to activate multiple signalling pathways [LiteratureReference:380120] Overview of the primary structure, tissue-distribution, and functions of tachykinins and their receptors
maxDepth	3
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Peptide ligand-binding receptors
orthologousEvent	[Pathway:R-CEL-375276] Peptide ligand-binding receptors - Caenorhabditis elegans [Pathway:R-DME-375276] Peptide ligand-binding receptors - Drosophila melanogaster [Pathway:R-GGA-375276] Peptide ligand-binding receptors - Gallus gallus [Pathway:R-XTR-375276] Peptide ligand-binding receptors - Xenopus tropicalis [Pathway:R-DRE-375276] Peptide ligand-binding receptors - Danio rerio [Pathway:R-SSC-375276] Peptide ligand-binding receptors - Sus scrofa [Pathway:R-BTA-375276] Peptide ligand-binding receptors - Bos taurus [Pathway:R-CFA-375276] Peptide ligand-binding receptors - Canis familiaris [Pathway:R-RNO-375276] Peptide ligand-binding receptors - Rattus norvegicus [Pathway:R-MMU-375276] Peptide ligand-binding receptors - Mus musculus
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2008-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:375494] Bockaert, J, 2008-09-01 12:04:13 [InstanceEdit:9953437] D'Eustachio, Peter, 2025-06-02
revised	[InstanceEdit:8948916] D'Eustachio, Peter, 2016-11-17
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-375276
summation	[Summation:375277] These receptors, a subset of the Class A/1 (Rhodopsin-like) ...
updateTrackers	[UpdateTracker:9791126] Update Tracker - [Pathway:375276] Peptide ligand-binding receptors - v32:[addHasEvent, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9780381] Update Tracker - [Pathway:375276] Peptide ligand-binding receptors - v63:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9787457] Update Tracker - [Pathway:375276] Peptide ligand-binding receptors - v45:[updateContainedPathway] [UpdateTracker:9778944] Update Tracker - [Pathway:375276] Peptide ligand-binding receptors - v67:[addHasEvent] [UpdateTracker:9953565] Update Tracker - [Pathway:375276] Peptide ligand-binding receptors - v93:[removeHasEvent] [UpdateTracker:9788656] Update Tracker - [Pathway:375276] Peptide ligand-binding receptors - v41:[addHasEvent] [UpdateTracker:9782793] Update Tracker - [Pathway:375276] Peptide ligand-binding receptors - v58:[updateContainedPathway] [UpdateTracker:9786499] Update Tracker - [Pathway:375276] Peptide ligand-binding receptors - v49:[addHasEvent] [UpdateTracker:9782271] Update Tracker - [Pathway:375276] Peptide ligand-binding receptors - v59:[addHasEvent, updateContainedPathway] [UpdateTracker:9790082] Update Tracker - [Pathway:375276] Peptide ligand-binding receptors - v35:[addHasEvent, updateContainedRLE] [UpdateTracker:9777521] Update Tracker - [Pathway:375276] Peptide ligand-binding receptors - v70:[updateContainedPathway] [UpdateTracker:9774712] Update Tracker - [Pathway:375276] Peptide ligand-binding receptors - v81:[addHasEvent, updateContainedPathway] [UpdateTracker:9775975] Update Tracker - [Pathway:375276] Peptide ligand-binding receptors - v78:[addHasEvent, updateContainedRLE] [UpdateTracker:9784200] Update Tracker - [Pathway:375276] Peptide ligand-binding receptors - v54:[addHasEvent] [UpdateTracker:9786288] Update Tracker - [Pathway:375276] Peptide ligand-binding receptors - v50:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9791607] Update Tracker - [Pathway:375276] Peptide ligand-binding receptors - v28:[addHasEvent, updateContainedRLE] [UpdateTracker:9788315] Update Tracker - [Pathway:375276] Peptide ligand-binding receptors - v43:[addHasEvent] [UpdateTracker:9791704] Update Tracker - [Pathway:375276] Peptide ligand-binding receptors - v27:[addLiteratureReference, add_removeHasEvent] [UpdateTracker:9779962] Update Tracker - [Pathway:375276] Peptide ligand-binding receptors - v64:[updateIndirectRLE] [UpdateTracker:9788410] Update Tracker - [Pathway:375276] Peptide ligand-binding receptors - v42:[removeHasEvent] [UpdateTracker:9787881] Update Tracker - [Pathway:375276] Peptide ligand-binding receptors - v44:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9783273] Update Tracker - [Pathway:375276] Peptide ligand-binding receptors - v57:[updateContainedPathway] [UpdateTracker:9779027] Update Tracker - [Pathway:375276] Peptide ligand-binding receptors - v66:[addHasEvent, updateContainedRLE] [UpdateTracker:9783600] Update Tracker - [Pathway:375276] Peptide ligand-binding receptors - v56:[updateContainedPathway, updateContainedRLE]

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[Pathway:R-HSA-373076] Class A/1 (Rhodopsin-like receptors)

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