Reactome | Peptide ligand-binding receptors

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Peptide ligand-binding receptors Show undefined attributes

created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10557069
displayName	Peptide ligand-binding receptors
eventOf	[Pathway:R-SSC-373076] Class A/1 (Rhodopsin-like receptors) - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SSC-374173] AGT(25-32) binds to AGTR1 - Sus scrofa [Reaction:R-SSC-9615348] AGT(25-32) binds to AGTR2 - Sus scrofa [Reaction:R-SSC-9615249] ARBs bind AGTR1 - Sus scrofa [Reaction:R-SSC-374337] Apelin receptor binds to apelin - Sus scrofa [Reaction:R-SSC-375384] Bombesin-like receptors bind bombesin homologues - Sus scrofa [Reaction:R-SSC-964811] C5AR2 binds anaphylatoxins and thier desArginated derivatives - Sus scrofa [Reaction:R-SSC-375395] C5a receptor binds C5a anaphylatoxin - Sus scrofa [Reaction:R-SSC-374251] DARC is a non-specific receptor for many chemokines - Sus scrofa [Reaction:R-SSC-374207] G protein-coupled estrogen receptor 1 binds estrogen non-classically - Sus scrofa [Reaction:R-SSC-374787] GPCR neuropeptide receptor binds neuropeptides B and W - Sus scrofa [Reaction:R-SSC-374723] Nociceptin receptor binds to nociceptin - Sus scrofa [Reaction:R-SSC-374298] Opioid receptors bind opioid peptides - Sus scrofa [Pathway:R-SSC-380108] Chemokine receptors bind chemokines - Sus scrofa [Reaction:R-SSC-374758] Somatostatin receptors bind somatostatin and cortistatin - Sus scrofa [Pathway:R-SSC-380095] Tachykinin receptors bind tachykinins - Sus scrofa [Pathway:R-SSC-388479] Vasopressin-like receptors - Sus scrofa [Reaction:R-SSC-8876868] ECE1 cleaves EDN1(53-90) - Sus scrofa [Reaction:R-SSC-8877620] ECE2 cleaves EDN1(53-90) - Sus scrofa [Reaction:R-SSC-5694082] XK:KEL:Zn2+ cleaves EDN3 - Sus scrofa [Reaction:R-SSC-388560] EDNRA,EDNRB bind EDNs - Sus scrofa [Reaction:R-SSC-9731924] EDNRA binds EDNs - Sus scrofa [Reaction:R-SSC-9731393] EDNRA, EDNRB bind non-selective ERAs - Sus scrofa [Reaction:R-SSC-9731931] EDNRA binds selective ERAs - Sus scrofa [Reaction:R-SSC-388596] Melanocortin receptors bind melanocortins - Sus scrofa [Reaction:R-SSC-388605] POMC(138-176) binds MC2R - Sus scrofa [Reaction:R-SSC-388855] Prolactin-releasing hormone receptor binds PRH - Sus scrofa [Reaction:R-SSC-388863] Neuropeptide Y receptors can bind neuropeptide Y-related peptides - Sus scrofa [Reaction:R-SSC-388900] Neurotensin receptors can bind neurotensins - Sus scrofa [Reaction:R-SSC-389026] Galanin receptors can bind galanin - Sus scrofa [Reaction:R-SSC-389463] Proteinase-activated receptors can bind thrombin - Sus scrofa [Pathway:R-SSC-389397] Orexin and neuropeptides FF and QRFP bind to their respective receptors - Sus scrofa [Reaction:R-SSC-444208] MLNR (GPR38) is a receptor for motilin - Sus scrofa [Reaction:R-SSC-444498] Thyrotropin-releasing hormone receptor binds thyrotropin - Sus scrofa [Reaction:R-SSC-444620] Neuropeptide S receptor binds neuropeptide S - Sus scrofa [Reaction:R-SSC-444691] Prokineticin receptors bind prokineticin - Sus scrofa [Pathway:R-SSC-444821] Relaxin receptors - Sus scrofa [Reaction:R-SSC-445113] Urotensin-2 receptor binds urotensin-2 and 2B - Sus scrofa [Reaction:R-SSC-947673] Melanin-concentrating hormone receptors bind MCH - Sus scrofa [Reaction:R-SSC-964800] Neuromedin-U receptors bind neuromedins U, S - Sus scrofa [Reaction:R-SSC-5336182] GPR37 binds prosaptide - Sus scrofa [Reaction:R-SSC-5336184] GPR37L binds prosaposin - Sus scrofa [Reaction:R-SSC-8940959] Neurolysin degrades neurotensin - Sus scrofa
inferredFrom	[Pathway:R-HSA-375276] Peptide ligand-binding receptors - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Peptide ligand-binding receptors
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-375276
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-373076] Class A/1 (Rhodopsin-like receptors)
(inferredTo)	[Pathway:R-HSA-375276] Peptide ligand-binding receptors

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