Reactome | Alamandine binds MRGPRD (MrgD)

Schema > Reaction > Entries

authored	[InstanceEdit:9944526] May, Bruce, 2025-04-04
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9944543] May, Bruce, 2025-04-05
dbId	9944544
displayName	Alamandine binds MRGPRD (MrgD)
edited	[InstanceEdit:9944526] May, Bruce, 2025-04-04
eventOf	[Pathway:R-HSA-375276] Peptide ligand-binding receptors - Homo sapiens
input	[GenomeEncodedEntity:R-HSA-9944519] Alamandine [extracellular region] [EntityWithAccessionedSequence:R-HSA-9944528] MRGPRD [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9944511] Discovery and characterization of alamandine: a novel component of the renin-angiotensin system
maxDepth	1
modified	[InstanceEdit:9976048] May, Bruce, 2025-12-06
name	Alamandine binds MRGPRD (MrgD)
output	[Complex:R-HSA-9944550] Alamandine:MRGPRD [plasma membrane]
precedingEvent	[Reaction:R-HSA-9944488] ACE2:Zn2+ cleaves 1-Ala-AGT(25-32) to yield Alamandine (1-Ala-AGT(25-31) - Homo sapiens [BlackBoxEvent:R-HSA-9944473] AGT(25-31) is decarboxylated to yield Alamandine - Homo sapiens
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9945952] Bader, Michael, 2025-04-20 [InstanceEdit:9945958] Touyz, Rhian M, 2025-04-20 [InstanceEdit:9945955] Santos, Robson Augusto Souza, 2025-04-20
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9944544
summation	[Summation:9944561] Alamandine is a decarboxylated form of the heptapeptide AGT(...

(hasEvent)

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