Reactome | Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.

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Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. Show undefined attributes

authored	[InstanceEdit:168344] Luo, F, 2005-11-16 12:05:41
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
dbId	450292
displayName	Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.
edited	[InstanceEdit:450362] Shamovsky, V, 2009-12-16
eventOf	[Pathway:R-HSA-450341] Activation of the AP-1 family of transcription factors - Homo sapiens [Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence - Homo sapiens [Pathway:R-HSA-2871796] FCERI mediated MAPK activation - Homo sapiens
followingEvent	[Reaction:R-HSA-3797196] AP-1 transcription factor binds IGFBP7 promoter - Homo sapiens [Reaction:R-HSA-4568737] AP-1 transcription factor binds IL1A promoter - Homo sapiens [Reaction:R-HSA-3222533] ERK1/2-activated AP1 complex binds KDM6B promoter - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-450237] p-S63,S73-JUN [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-450283] p-T325,T331,S362,S374-FOS [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:169947] Regulatory mechanisms involved in activator-protein-1 (AP-1)-mediated activation of glutathione-S-transferase gene expression by chemical agents [LiteratureReference:208105] Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.
orthologousEvent	[Reaction:R-CEL-450292] Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. - Caenorhabditis elegans [Reaction:R-DME-450292] Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. - Drosophila melanogaster [Reaction:R-GGA-450292] Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. - Gallus gallus [Reaction:R-XTR-450292] Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. - Xenopus tropicalis [Reaction:R-DRE-450292] Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. - Danio rerio [Reaction:R-SSC-450292] Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. - Sus scrofa [Reaction:R-BTA-450292] Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. - Bos taurus [Reaction:R-CFA-450292] Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. - Canis familiaris [Reaction:R-RNO-450292] Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. - Rattus norvegicus [Reaction:R-MMU-450292] Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. - Mus musculus
output	[Complex:R-HSA-450327] p-2S-cJUN:p-2S,2T-cFOS [nucleoplasm]
precedingEvent	[Reaction:R-HSA-168136] Activated JNKs phosphorylate c-JUN - Homo sapiens [Reaction:R-HSA-450325] c-FOS activation by phospho ERK1/2 - Homo sapiens
releaseDate	2010-03-16
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17
revised	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-450292
summation	[Summation:500515] The bZIP domains of Jun and Fos form an X-shaped -helical st...

Referrals

(hasEvent)	[Pathway:R-HSA-2871796] FCERI mediated MAPK activation [Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence [Pathway:R-HSA-450341] Activation of the AP-1 family of transcription factors
(precedingEvent)	[Reaction:R-HSA-3797196] AP-1 transcription factor binds IGFBP7 promoter [Reaction:R-HSA-4568737] AP-1 transcription factor binds IL1A promoter [Reaction:R-HSA-3222533] ERK1/2-activated AP1 complex binds KDM6B promoter

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