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Reaction
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Entries
Phosphorylation of human JNKs by activated MKK4/MKK7
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authored
[InstanceEdit:167907] Luo, F, 2005-11-10 11:23:18
catalystActivity
[CatalystActivity:450334] JUN kinase kinase activity of p-MAP2K4/p-MAP2K7 [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:168183] Gillespie, ME, 2005-11-10 16:33:34
dbId
168162
displayName
Phosphorylation of human JNKs by activated MKK4/MKK7
edited
[InstanceEdit:450361] Shamovsky, V, 2009-12-16
eventOf
[Pathway:R-HSA-450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 - Homo sapiens
[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence - Homo sapiens
[Pathway:R-HSA-2871796] FCERI mediated MAPK activation - Homo sapiens
followingEvent
[Reaction:R-HSA-450348] Activated human JNKs migrate to nucleoplasm - Homo sapiens
input
2 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[DefinedSet:R-HSA-450289] MAPK8,9,10 [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:169962] Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo.
[LiteratureReference:438014] Essential function for the kinase TAK1 in innate and adaptive immune responses
[LiteratureReference:444056] Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death
modified
[InstanceEdit:10818988] Wright, Adam, 2024-03-08
name
Phosphorylation of human JNKs by activated MKK4/MKK7
orthologousEvent
[Reaction:R-GGA-438005] MKK4 phosphorylates JNK - Gallus gallus
[Reaction:R-DDI-168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - Dictyostelium discoideum
[Reaction:R-CEL-168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - Caenorhabditis elegans
[Reaction:R-DME-168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - Drosophila melanogaster
[Reaction:R-GGA-168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - Gallus gallus
[Reaction:R-DRE-168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - Danio rerio
[Reaction:R-SSC-168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - Sus scrofa
[Reaction:R-BTA-168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - Bos taurus
[Reaction:R-CFA-168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - Canis familiaris
[Reaction:R-RNO-168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - Rattus norvegicus
[Reaction:R-MMU-168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - Mus musculus
output
2 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[DefinedSet:R-HSA-450226] p-MAPK8,9,10 [cytosol]
precedingEvent
[Reaction:R-HSA-450337] Activated TAK1 phosphorylates MKK4/MKK7 - Homo sapiens
[Reaction:R-HSA-2730868] Phosphorylation of MEK7 by MEKK1 - Homo sapiens
releaseDate
2010-12-14
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17
revised
[InstanceEdit:450323] Shamovsky, V, 2009-12-16
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-168162
summation
[Summation:450223] Activated human JNK kinases (MKK4 and MKK7) phosphorylate T...
Referrals
(hasEvent)
[Pathway:R-HSA-2871796] FCERI mediated MAPK activation
[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence
[Pathway:R-HSA-450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
(precedingEvent)
[Reaction:R-HSA-450348] Activated human JNKs migrate to nucleoplasm
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