Reactome | Phosphorylation of human JNKs by activated MKK4/MKK7

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Phosphorylation of human JNKs by activated MKK4/MKK7 Show undefined attributes

authored	[InstanceEdit:167907] Luo, F, 2005-11-10 11:23:18
catalystActivity	[CatalystActivity:450334] JUN kinase kinase activity of p-MAP2K4/p-MAP2K7 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:168183] Gillespie, ME, 2005-11-10 16:33:34
dbId	168162
displayName	Phosphorylation of human JNKs by activated MKK4/MKK7
edited	[InstanceEdit:450361] Shamovsky, V, 2009-12-16
eventOf	[Pathway:R-HSA-450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 - Homo sapiens [Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence - Homo sapiens [Pathway:R-HSA-2871796] FCERI mediated MAPK activation - Homo sapiens
followingEvent	[Reaction:R-HSA-450348] Activated human JNKs migrate to nucleoplasm - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-HSA-450289] MAPK8,9,10 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:169962] Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo. [LiteratureReference:438014] Essential function for the kinase TAK1 in innate and adaptive immune responses [LiteratureReference:444056] Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Phosphorylation of human JNKs by activated MKK4/MKK7
orthologousEvent	[Reaction:R-GGA-438005] MKK4 phosphorylates JNK - Gallus gallus [Reaction:R-CEL-168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - Caenorhabditis elegans [Reaction:R-DME-168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - Drosophila melanogaster [Reaction:R-GGA-168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - Gallus gallus [Reaction:R-XTR-168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - Xenopus tropicalis [Reaction:R-DRE-168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - Danio rerio [Reaction:R-SSC-168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - Sus scrofa [Reaction:R-BTA-168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - Bos taurus [Reaction:R-CFA-168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - Canis familiaris [Reaction:R-RNO-168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - Rattus norvegicus [Reaction:R-MMU-168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-HSA-450226] p-MAPK8,9,10 [cytosol]
precedingEvent	[Reaction:R-HSA-450337] Activated TAK1 phosphorylates MKK4/MKK7 - Homo sapiens [Reaction:R-HSA-2730868] Phosphorylation of MEK7 by MEKK1 - Homo sapiens
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17
revised	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-168162
summation	[Summation:450223] Activated human JNK kinases (MKK4 and MKK7) phosphorylate T...
updateTrackers	[UpdateTracker:9790911] Update Tracker - [Reaction:168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - v32:[addLiteratureReference, add_removeCatalystActivity, add_removeInput, add_removeOutput, add_removeSummation] [UpdateTracker:9791789] Update Tracker - [Reaction:168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - v25:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9790911] Update Tracker - [Reaction:168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - v32:[addLiteratureReference, add_removeCatalystActivity, add_removeInput, add_removeOutput, add_removeSummation] [UpdateTracker:9791789] Update Tracker - [Reaction:168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - v25:[add_removeOutput]
(hasEvent)	[Pathway:R-HSA-2871796] FCERI mediated MAPK activation [Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence [Pathway:R-HSA-450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
(precedingEvent)	[Reaction:R-HSA-450348] Activated human JNKs migrate to nucleoplasm

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