Reactome | Recruitment of PAK to the membrane by binding active RAC1

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Recruitment of PAK to the membrane by binding active RAC1 Show undefined attributes

authored	[InstanceEdit:2871799] Niarakis, Anna, 2012-12-21
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:2730834] Garapati, P V, 2012-12-05
dbId	2730889
displayName	Recruitment of PAK to the membrane by binding active RAC1
edited	[InstanceEdit:2454233] Garapati, P V, 2012-08-22
eventOf	[Pathway:R-HSA-2871796] FCERI mediated MAPK activation - Homo sapiens
followingEvent	[Reaction:R-HSA-2730856] Autophosphorylation of PAK - Homo sapiens
input	[Complex:R-HSA-2685706] p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] [DefinedSet:R-HSA-2685646] PAK dimer [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2685488] p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics [LiteratureReference:2685447] Dissecting activation of the PAK1 kinase at protrusions in living cells [LiteratureReference:419744] PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation [LiteratureReference:2685479] Mechanism of activation of Pak1 kinase by membrane localization
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Recruitment of PAK to the membrane by binding active RAC1
orthologousEvent	[Reaction:R-DME-2730889] Recruitment of PAK to the membrane by binding active RAC1 - Drosophila melanogaster [Reaction:R-GGA-2730889] Recruitment of PAK to the membrane by binding active RAC1 - Gallus gallus [Reaction:R-XTR-2730889] Recruitment of PAK to the membrane by binding active RAC1 - Xenopus tropicalis [Reaction:R-SSC-2730889] Recruitment of PAK to the membrane by binding active RAC1 - Sus scrofa [Reaction:R-BTA-2730889] Recruitment of PAK to the membrane by binding active RAC1 - Bos taurus [Reaction:R-CFA-2730889] Recruitment of PAK to the membrane by binding active RAC1 - Canis familiaris [Reaction:R-RNO-2730889] Recruitment of PAK to the membrane by binding active RAC1 - Rattus norvegicus [Reaction:R-MMU-2730889] Recruitment of PAK to the membrane by binding active RAC1 - Mus musculus
output	[Complex:R-HSA-2685694] p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane]
precedingEvent	[Reaction:R-HSA-2730840] Activation of RAC1 by VAV - Homo sapiens
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3139040] Roncagalli, Romain, 2013-02-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2730889
summation	[Summation:2685569] PAK1 kinase is a member of serine/threonine protein kinase f...

Referrals

(hasEvent)	[Pathway:R-HSA-2871796] FCERI mediated MAPK activation
(precedingEvent)	[Reaction:R-HSA-2730856] Autophosphorylation of PAK