Reactome | c-FOS activation by phospho ERK1/2

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c-FOS activation by phospho ERK1/2 Show undefined attributes

authored	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
catalystActivity	[CatalystActivity:198713] protein serine/threonine kinase activity of p-T,Y MAPK dimers [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
dbId	450325
displayName	c-FOS activation by phospho ERK1/2
edited	[InstanceEdit:532463] Shamovsky, V, 2010-02-27
eventOf	[Pathway:R-HSA-450341] Activation of the AP-1 family of transcription factors - Homo sapiens [Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence - Homo sapiens [Pathway:R-HSA-2871796] FCERI mediated MAPK activation - Homo sapiens
followingEvent	[Reaction:R-HSA-450292] Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. - Homo sapiens
input	4 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-450216] FOS [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:450266] The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells [LiteratureReference:450340] Molecular interpretation of ERK signal duration by immediate early gene products
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	c-FOS activation by phospho ERK1/2
orthologousEvent	[Reaction:R-CEL-450325] c-FOS activation by phospho ERK1/2 - Caenorhabditis elegans [Reaction:R-DME-450325] c-FOS activation by phospho ERK1/2 - Drosophila melanogaster [Reaction:R-GGA-450325] c-FOS activation by phospho ERK1/2 - Gallus gallus [Reaction:R-XTR-450325] c-FOS activation by phospho ERK1/2 - Xenopus tropicalis [Reaction:R-DRE-450325] c-FOS activation by phospho ERK1/2 - Danio rerio [Reaction:R-SSC-450325] c-FOS activation by phospho ERK1/2 - Sus scrofa [Reaction:R-BTA-450325] c-FOS activation by phospho ERK1/2 - Bos taurus [Reaction:R-CFA-450325] c-FOS activation by phospho ERK1/2 - Canis familiaris [Reaction:R-RNO-450325] c-FOS activation by phospho ERK1/2 - Rattus norvegicus [Reaction:R-MMU-450325] c-FOS activation by phospho ERK1/2 - Mus musculus
output	4 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-450283] p-T325,T331,S362,S374-FOS [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-5674387] Phosphorylated MAPKs translocate into the nucleus - Homo sapiens
releaseDate	2010-03-16
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:532466] Gillespie, ME, 2010-02-27
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-450325
summation	[Summation:450350] The Fos proteins(c-Fos, FosB, Fra1 and Fra2), which cannot h...

Referrals

(hasEvent)	[Pathway:R-HSA-2871796] FCERI mediated MAPK activation [Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence [Pathway:R-HSA-450341] Activation of the AP-1 family of transcription factors
(precedingEvent)	[Reaction:R-HSA-450292] Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.