Reactome | Autophosphorylation of PAK

Schema > Reaction > Entries

Autophosphorylation of PAK Show undefined attributes

authored	[InstanceEdit:2871799] Niarakis, Anna, 2012-12-21
catalystActivity	[CatalystActivity:2730883] protein serine/threonine kinase activity of p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9644042] protein serine/threonine kinase activity of p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:2730834] Garapati, P V, 2012-12-05
dbId	2730856
displayName	Autophosphorylation of PAK
edited	[InstanceEdit:2454233] Garapati, P V, 2012-08-22
eventOf	[Pathway:R-HSA-2871796] FCERI mediated MAPK activation - Homo sapiens
followingEvent	[Reaction:R-HSA-2730887] Autophosphorylation and activation of MEKK1 - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-2685694] p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2028849] Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1 [LiteratureReference:399908] The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Autophosphorylation of PAK
orthologousEvent	[Reaction:R-DME-2730856] Autophosphorylation of PAK - Drosophila melanogaster [Reaction:R-GGA-2730856] Autophosphorylation of PAK - Gallus gallus [Reaction:R-XTR-2730856] Autophosphorylation of PAK - Xenopus tropicalis [Reaction:R-SSC-2730856] Autophosphorylation of PAK - Sus scrofa [Reaction:R-BTA-2730856] Autophosphorylation of PAK - Bos taurus [Reaction:R-CFA-2730856] Autophosphorylation of PAK - Canis familiaris [Reaction:R-RNO-2730856] Autophosphorylation of PAK - Rattus norvegicus [Reaction:R-MMU-2730856] Autophosphorylation of PAK - Mus musculus
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] 2 × [DefinedSet:R-HSA-5567354] p-2Y-PAK [cytosol] [Complex:R-HSA-2685706] p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-2730889] Recruitment of PAK to the membrane by binding active RAC1 - Homo sapiens
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3139040] Roncagalli, Romain, 2013-02-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2730856
summation	[Summation:2685551] Upon dimer disassociation PAK1 autophosphorylates in both ci...
updateTrackers	[UpdateTracker:9786699] Update Tracker - [Reaction:2730856] Autophosphorylation of PAK - v49:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9786699] Update Tracker - [Reaction:2730856] Autophosphorylation of PAK - v49:[add_removeOutput]
(hasEvent)	[Pathway:R-HSA-2871796] FCERI mediated MAPK activation
(precedingEvent)	[Reaction:R-HSA-2730887] Autophosphorylation and activation of MEKK1