Reactome | Activated JNKs phosphorylate c-JUN

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Activated JNKs phosphorylate c-JUN Show undefined attributes

authored	[InstanceEdit:167907] Luo, F, 2005-11-10 11:23:18
catalystActivity	[CatalystActivity:450228] JUN kinase activity of p-MAPK8,9,10 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:168183] Gillespie, ME, 2005-11-10 16:33:34
dbId	168136
displayName	Activated JNKs phosphorylate c-JUN
edited	[InstanceEdit:450360] Shamovsky, V, 2009-12-16
eventOf	[Pathway:R-HSA-450341] Activation of the AP-1 family of transcription factors - Homo sapiens [Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence - Homo sapiens [Pathway:R-HSA-2871796] FCERI mediated MAPK activation - Homo sapiens
followingEvent	[Reaction:R-HSA-168440] Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer. - Homo sapiens [Reaction:R-HSA-450292] Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. - Homo sapiens
input	2 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-450250] JUN [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:169974] c-Jun inhibits transforming growth factor beta-mediated transcription by repressing Smad3 transcriptional activity [LiteratureReference:437979] c-Jun expression, activation and function in neural cell death, inflammation and repair
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Activated JNKs phosphorylate c-JUN
orthologousEvent	[Reaction:R-GGA-438026] Activation and dimerization of c-JUN in the nucleus - Gallus gallus [Reaction:R-GGA-168136] Activated JNKs phosphorylate c-JUN - Gallus gallus [Reaction:R-XTR-168136] Activated JNKs phosphorylate c-JUN - Xenopus tropicalis [Reaction:R-DRE-168136] Activated JNKs phosphorylate c-JUN - Danio rerio [Reaction:R-SSC-168136] Activated JNKs phosphorylate c-JUN - Sus scrofa [Reaction:R-BTA-168136] Activated JNKs phosphorylate c-JUN - Bos taurus [Reaction:R-CFA-168136] Activated JNKs phosphorylate c-JUN - Canis familiaris [Reaction:R-RNO-168136] Activated JNKs phosphorylate c-JUN - Rattus norvegicus [Reaction:R-MMU-168136] Activated JNKs phosphorylate c-JUN - Mus musculus
output	2 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-450237] p-S63,S73-JUN [nucleoplasm]
precedingEvent	[Reaction:R-HSA-450348] Activated human JNKs migrate to nucleoplasm - Homo sapiens
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17
revised	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-168136
summation	[Summation:169953] JNK (c-Jun N-terminal Kinase) phosphorylates several transcr...

Referrals

(hasEvent)	[Pathway:R-HSA-2871796] FCERI mediated MAPK activation [Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence [Pathway:R-HSA-450341] Activation of the AP-1 family of transcription factors
(precedingEvent)	[Reaction:R-HSA-168440] Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer. [Reaction:R-HSA-450292] Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.

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