Reactome | Phosphorylation of MEK7 by MEKK1

Schema > Reaction > Entries

Phosphorylation of MEK7 by MEKK1 Show undefined attributes

authored	[InstanceEdit:2871799] Niarakis, Anna, 2012-12-21
catalystActivity	[CatalystActivity:2730874] protein serine/threonine kinase activity of p-T1400,T1412-MAP3K1 [cytosol]
catalystActivityReference	[CatalystActivityReference:9644760] protein serine/threonine kinase activity of p-T1400,T1412-MAP3K1 [cytosol] Differential activation of stress-activated protein kinase kinases SKK4/MKK7 and SKK1/MKK4 by the mixed-lineage kinase-2 and mitogen-activated protein kinase kinase (MKK) kinase-1
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2730834] Garapati, P V, 2012-12-05
dbId	2730868
displayName	Phosphorylation of MEK7 by MEKK1
edited	[InstanceEdit:2454233] Garapati, P V, 2012-08-22
eventOf	[Pathway:R-HSA-2871796] FCERI mediated MAPK activation - Homo sapiens
followingEvent	[Reaction:R-HSA-168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-450276] MAP2K7 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2685096] Differential activation of stress-activated protein kinase kinases SKK4/MKK7 and SKK1/MKK4 by the mixed-lineage kinase-2 and mitogen-activated protein kinase kinase (MKK) kinase-1 [LiteratureReference:2685143] Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Phosphorylation of MEK7 by MEKK1
orthologousEvent	[Reaction:R-SCE-2730868] Phosphorylation of MEK7 by MEKK1 - Saccharomyces cerevisiae [Reaction:R-SPO-2730868] Phosphorylation of MEK7 by MEKK1 - Schizosaccharomyces pombe [Reaction:R-DDI-2730868] Phosphorylation of MEK7 by MEKK1 - Dictyostelium discoideum [Reaction:R-CFA-2730868] Phosphorylation of MEK7 by MEKK1 - Canis familiaris [Reaction:R-RNO-2730868] Phosphorylation of MEK7 by MEKK1 - Rattus norvegicus [Reaction:R-MMU-2730868] Phosphorylation of MEK7 by MEKK1 - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-450353] p-S271,T275-MAP2K7 [cytosol]
precedingEvent	[Reaction:R-HSA-2730887] Autophosphorylation and activation of MEKK1 - Homo sapiens
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3139040] Roncagalli, Romain, 2013-02-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2730868
summation	[Summation:2685564] MKK7 is activated by MEKK1 and the residues serine 271 and t...

Referrals

(hasEvent)	[Pathway:R-HSA-2871796] FCERI mediated MAPK activation
(precedingEvent)	[Reaction:R-HSA-168162] Phosphorylation of human JNKs by activated MKK4/MKK7