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Entries
CD28 dependent PI3K/Akt signaling
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authored
[InstanceEdit:388810] Garapati, P V, 2008-12-16 11:12:19
created
[InstanceEdit:389358] Garapati, P V, 2009-01-06 13:43:48
crossReference
[DatabaseIdentifier:12325424] BioModels Database:BIOMD0000000255
[DatabaseIdentifier:12325426] BioModels Database:BIOMD0000000581
[DatabaseIdentifier:12325600] BioModels Database:BIOMD0000000465
[DatabaseIdentifier:12325562] BioModels Database:BIOMD0000000943
[DatabaseIdentifier:12325430] BioModels Database:BIOMD0000000175
[DatabaseIdentifier:12325644] BioModels Database:BIOMD0000000356
[DatabaseIdentifier:12325346] BioModels Database:BIOMD0000000883
[DatabaseIdentifier:12325480] BioModels Database:BIOMD0000000468
dbId
389357
displayName
CD28 dependent PI3K/Akt signaling
edited
[InstanceEdit:388810] Garapati, P V, 2008-12-16 11:12:19
eventOf
[Pathway:R-HSA-389356] CD28 co-stimulation - Homo sapiens
figure
[Figure:389346] /figures/CD28_PI3K.png
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-388832] PI3K binds CD28 - Homo sapiens
[Reaction:R-HSA-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 - Homo sapiens
[Reaction:R-HSA-2316429] PIP3 recruits PDPK1 to the membrane - Homo sapiens
[Reaction:R-HSA-2317332] PIP3 recruits AKT to the membrane - Homo sapiens
[Reaction:R-HSA-198640] TORC2 (mTOR) phosphorylates AKT at S473 - Homo sapiens
[Reaction:R-HSA-2317314] AKT binds PDPK1 - Homo sapiens
[Reaction:R-HSA-198270] PDPK1 phosphorylates AKT at T308 - Homo sapiens
[Reaction:R-HSA-389756] AKT interacts and phosphorylates Cot - Homo sapiens
[Reaction:R-HSA-392530] p-S400-Cot phosphorylates NIK - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:389305] Phosphoinositide 3-kinase in T cell activation and survival
[LiteratureReference:389297] The PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3
modified
[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name
CD28 dependent PI3K/Akt signaling
orthologousEvent
[Pathway:R-PFA-389357] CD28 dependent PI3K/Akt signaling - Plasmodium falciparum
[Pathway:R-SCE-389357] CD28 dependent PI3K/Akt signaling - Saccharomyces cerevisiae
[Pathway:R-SPO-389357] CD28 dependent PI3K/Akt signaling - Schizosaccharomyces pombe
[Pathway:R-DDI-389357] CD28 dependent PI3K/Akt signaling - Dictyostelium discoideum
[Pathway:R-CEL-389357] CD28 dependent PI3K/Akt signaling - Caenorhabditis elegans
[Pathway:R-DME-389357] CD28 dependent PI3K/Akt signaling - Drosophila melanogaster
[Pathway:R-GGA-389357] CD28 dependent PI3K/Akt signaling - Gallus gallus
[Pathway:R-XTR-389357] CD28 dependent PI3K/Akt signaling - Xenopus tropicalis
[Pathway:R-DRE-389357] CD28 dependent PI3K/Akt signaling - Danio rerio
[Pathway:R-SSC-389357] CD28 dependent PI3K/Akt signaling - Sus scrofa
[Pathway:R-BTA-389357] CD28 dependent PI3K/Akt signaling - Bos taurus
[Pathway:R-CFA-389357] CD28 dependent PI3K/Akt signaling - Canis familiaris
[Pathway:R-RNO-389357] CD28 dependent PI3K/Akt signaling - Rattus norvegicus
[Pathway:R-MMU-389357] CD28 dependent PI3K/Akt signaling - Mus musculus
releaseDate
2009-09-30
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:422514] Bluestone, JA, Esensten, J, 2009-06-01 18:47:33
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-389357
summation
[Summation:389293] PI3Ks can be activated by a number of different receptors, i...
Referrals
(hasEvent)
[Pathway:R-HSA-389356] CD28 co-stimulation
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