Reactome | CD28 dependent PI3K/Akt signaling

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CD28 dependent PI3K/Akt signaling Show undefined attributes

authored	[InstanceEdit:388810] Garapati, P V, 2008-12-16 11:12:19
created	[InstanceEdit:389358] Garapati, P V, 2009-01-06 13:43:48
crossReference	[DatabaseIdentifier:12819465] BioModels Database:BIOMD0000000255 [DatabaseIdentifier:12819685] BioModels Database:BIOMD0000000137 [DatabaseIdentifier:12819467] BioModels Database:BIOMD0000000581 [DatabaseIdentifier:12819643] BioModels Database:BIOMD0000000465 [DatabaseIdentifier:12819581] BioModels Database:BIOMD0000000943 [DatabaseIdentifier:12819471] BioModels Database:BIOMD0000000175 [DatabaseIdentifier:12819651] BioModels Database:BIOMD0000000356 [DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883 [DatabaseIdentifier:12819511] BioModels Database:BIOMD0000000468
dbId	389357
displayName	CD28 dependent PI3K/Akt signaling
edited	[InstanceEdit:388810] Garapati, P V, 2008-12-16 11:12:19
eventOf	[Pathway:R-HSA-389356] Co-stimulation by CD28 - Homo sapiens
figure	[Figure:389346] /figures/CD28_PI3K.png
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-388832] PI3K binds CD28 - Homo sapiens [Reaction:R-HSA-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-2316429] PIP3 recruits PDPK1 to the membrane - Homo sapiens [Reaction:R-HSA-2317332] PIP3 recruits AKT to the membrane - Homo sapiens [Reaction:R-HSA-198640] mTORC2 phosphorylates AKT at S473 - Homo sapiens [Reaction:R-HSA-2317314] AKT binds PDPK1 - Homo sapiens [Reaction:R-HSA-198270] PDPK1 phosphorylates AKT at T308 - Homo sapiens [Reaction:R-HSA-389756] AKT interacts and phosphorylates Cot - Homo sapiens [Reaction:R-HSA-392530] p-S400-Cot phosphorylates NIK - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-04-07
literatureReference	[LiteratureReference:389305] Phosphoinositide 3-kinase in T cell activation and survival [LiteratureReference:389297] The PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	CD28 dependent PI3K/Akt signaling
orthologousEvent	[Pathway:R-MMU-389357] CD28 dependent PI3K/Akt signaling - Mus musculus [Pathway:R-RNO-389357] CD28 dependent PI3K/Akt signaling - Rattus norvegicus [Pathway:R-CFA-389357] CD28 dependent PI3K/Akt signaling - Canis familiaris [Pathway:R-BTA-389357] CD28 dependent PI3K/Akt signaling - Bos taurus [Pathway:R-SSC-389357] CD28 dependent PI3K/Akt signaling - Sus scrofa [Pathway:R-DRE-389357] CD28 dependent PI3K/Akt signaling - Danio rerio [Pathway:R-XTR-389357] CD28 dependent PI3K/Akt signaling - Xenopus tropicalis [Pathway:R-GGA-389357] CD28 dependent PI3K/Akt signaling - Gallus gallus [Pathway:R-CEL-389357] CD28 dependent PI3K/Akt signaling - Caenorhabditis elegans [Pathway:R-DDI-389357] CD28 dependent PI3K/Akt signaling - Dictyostelium discoideum [Pathway:R-SPO-389357] CD28 dependent PI3K/Akt signaling - Schizosaccharomyces pombe [Pathway:R-SCE-389357] CD28 dependent PI3K/Akt signaling - Saccharomyces cerevisiae [Pathway:R-PFA-389357] CD28 dependent PI3K/Akt signaling - Plasmodium falciparum [Pathway:R-DME-389357] CD28 dependent PI3K/Akt signaling - Drosophila melanogaster
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422514] Bluestone, JA, Esensten, J, 2009-06-01 18:47:33
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-389357
summation	[Summation:389293] CD28-mediated PI3K signaling plays a crucial role in augment...
updateTrackers	[UpdateTracker:9789173] Update Tracker - [Pathway:389357] CD28 dependent PI3K/Akt signaling - v38:[addLiteratureReference, updateContainedRLE] [UpdateTracker:9788400] Update Tracker - [Pathway:389357] CD28 dependent PI3K/Akt signaling - v42:[add_removeHasEvent, updateContainedRLE] [UpdateTracker:9790914] Update Tracker - [Pathway:389357] CD28 dependent PI3K/Akt signaling - v32:[updateContainedRLE] [UpdateTracker:9791368] Update Tracker - [Pathway:389357] CD28 dependent PI3K/Akt signaling - v31:[updateContainedRLE] [UpdateTracker:9774891] Update Tracker - [Pathway:389357] CD28 dependent PI3K/Akt signaling - v80:[updateContainedRLE] [UpdateTracker:9928464] Update Tracker - [Pathway:389357] CD28 dependent PI3K/Akt signaling - v91:[modifyText]

Referrals

(hasEvent)

[Pathway:R-HSA-389356] Co-stimulation by CD28

(updatedInstance)

[UpdateTracker:9789173] Update Tracker - [Pathway:389357] CD28 dependent PI3K/Akt signaling - v38:[addLiteratureReference, updateContainedRLE]
[UpdateTracker:9788400] Update Tracker - [Pathway:389357] CD28 dependent PI3K/Akt signaling - v42:[add_removeHasEvent, updateContainedRLE]
[UpdateTracker:9790914] Update Tracker - [Pathway:389357] CD28 dependent PI3K/Akt signaling - v32:[updateContainedRLE]
[UpdateTracker:9791368] Update Tracker - [Pathway:389357] CD28 dependent PI3K/Akt signaling - v31:[updateContainedRLE]
[UpdateTracker:9774891] Update Tracker - [Pathway:389357] CD28 dependent PI3K/Akt signaling - v80:[updateContainedRLE]
[UpdateTracker:9928464] Update Tracker - [Pathway:389357] CD28 dependent PI3K/Akt signaling - v91:[modifyText]

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