Reactome | VEGFR2 mediated vascular permeability

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VEGFR2 mediated vascular permeability Show undefined attributes

authored	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5218919] Garapati, P V, 2013-12-20
crossReference	[DatabaseIdentifier:12325464] BioModels Database:BIOMD0000000467 [DatabaseIdentifier:12325426] BioModels Database:BIOMD0000000581 [DatabaseIdentifier:12325346] BioModels Database:BIOMD0000000883 [DatabaseIdentifier:12325480] BioModels Database:BIOMD0000000468
dbId	5218920
displayName	VEGFR2 mediated vascular permeability
edited	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
eventOf	[Pathway:R-HSA-4420097] VEGFA-VEGFR2 Pathway - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5357483] RAC1 binds PAK1-3 - Homo sapiens [Reaction:R-HSA-5357445] PAK1-3 dimer disassociates - Homo sapiens [Reaction:R-HSA-5357472] PAK1-3 autophosphorylates - Homo sapiens [Reaction:R-HSA-5357477] PAK1-3 phosphorylates VE-cadherin - Homo sapiens [Reaction:R-HSA-2316429] PIP3 recruits PDPK1 to the membrane - Homo sapiens [Reaction:R-HSA-198640] TORC2 (mTOR) phosphorylates AKT at S473 - Homo sapiens [Reaction:R-HSA-2317314] AKT binds PDPK1 - Homo sapiens [Reaction:R-HSA-198270] PDPK1 phosphorylates AKT at T308 - Homo sapiens [Reaction:R-HSA-202110] eNOS:Caveolin-1 complex binds to CaM - Homo sapiens [Reaction:R-HSA-202129] HSP90 binds eNOS:Caveolin-1:CaM complex - Homo sapiens [Reaction:R-HSA-202144] Caveolin-1 dissociates from eNOS:CaM:HSP90 complex - Homo sapiens [Reaction:R-HSA-202137] AKT1 binds eNOS complex via HSP90 - Homo sapiens [Reaction:R-HSA-202111] AKT1 phosphorylates eNOS - Homo sapiens [Reaction:R-HSA-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle - Homo sapiens [Reaction:R-HSA-202127] eNOS synthesizes NO - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5218535] Vascular endothelial growth factor signaling to endothelial nitric oxide synthase: more than a FLeeTing moment
modified	[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name	VEGFR2 mediated vascular permeability
orthologousEvent	[Pathway:R-PFA-5218920] VEGFR2 mediated vascular permeability - Plasmodium falciparum [Pathway:R-SCE-5218920] VEGFR2 mediated vascular permeability - Saccharomyces cerevisiae [Pathway:R-SPO-5218920] VEGFR2 mediated vascular permeability - Schizosaccharomyces pombe [Pathway:R-DDI-5218920] VEGFR2 mediated vascular permeability - Dictyostelium discoideum [Pathway:R-CEL-5218920] VEGFR2 mediated vascular permeability - Caenorhabditis elegans [Pathway:R-DME-5218920] VEGFR2 mediated vascular permeability - Drosophila melanogaster [Pathway:R-GGA-5218920] VEGFR2 mediated vascular permeability - Gallus gallus [Pathway:R-XTR-5218920] VEGFR2 mediated vascular permeability - Xenopus tropicalis [Pathway:R-DRE-5218920] VEGFR2 mediated vascular permeability - Danio rerio [Pathway:R-SSC-5218920] VEGFR2 mediated vascular permeability - Sus scrofa [Pathway:R-BTA-5218920] VEGFR2 mediated vascular permeability - Bos taurus [Pathway:R-CFA-5218920] VEGFR2 mediated vascular permeability - Canis familiaris [Pathway:R-RNO-5218920] VEGFR2 mediated vascular permeability - Rattus norvegicus [Pathway:R-MMU-5218920] VEGFR2 mediated vascular permeability - Mus musculus
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5432673] Welsh, Michael, Berger, Philipp, Ballmer-Hofer, Kurt, 2014-05-12
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5218920
summation	[Summation:5218485] The free radical nitric oxide (NO), produced by endothelial ...

Referrals

(hasEvent)

[Pathway:R-HSA-4420097] VEGFA-VEGFR2 Pathway

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