Reactome | PIP3 recruits PDPK1 to the membrane

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PIP3 recruits PDPK1 to the membrane Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10044102
displayName	PIP3 recruits PDPK1 to the membrane
eventOf	[Pathway:R-MMU-389357] CD28 dependent PI3K/Akt signaling - Mus musculus [Pathway:R-MMU-1257604] PIP3 activates AKT signaling - Mus musculus [Pathway:R-MMU-5218920] VEGFR2 mediated vascular permeability - Mus musculus [Pathway:R-MMU-114604] GPVI-mediated activation cascade - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-2317314] AKT binds PDPK1 - Mus musculus
inferredFrom	[Reaction:R-HSA-2316429] PIP3 recruits PDPK1 to the membrane - Homo sapiens
input	[EntityWithAccessionedSequence:R-MMU-202210] PDPK1 [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PIP3 recruits PDPK1 to the membrane
output	[Complex:R-MMU-109697] PDPK1:PIP3 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-MMU-198266] PI3K produces PIP3 and other phosphatidyl inositides - Mus musculus [Reaction:R-MMU-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 - Mus musculus [Reaction:R-MMU-202365] PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 - Mus musculus [Reaction:R-MMU-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 - Mus musculus [Reaction:R-MMU-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Mus musculus [Reaction:R-MMU-2045911] BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 - Mus musculus [Reaction:R-MMU-2076220] CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 - Mus musculus [Reaction:R-MMU-2316434] PI3K phosphorylates PIP2 to PIP3 - Mus musculus [Reaction:R-MMU-5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-2316429
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-114604] GPVI-mediated activation cascade [Pathway:R-MMU-5218920] VEGFR2 mediated vascular permeability [Pathway:R-MMU-389357] CD28 dependent PI3K/Akt signaling [Pathway:R-MMU-1257604] PIP3 activates AKT signaling
(precedingEvent)	[Reaction:R-MMU-2317314] AKT binds PDPK1
(inferredTo)	[Reaction:R-HSA-2316429] PIP3 recruits PDPK1 to the membrane

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