Reactome | Activated NOTCH1 Transmits Signal to the Nucleus

Schema > Pathway > Entries

Activated NOTCH1 Transmits Signal to the Nucleus Show undefined attributes

authored	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:2122949] Orlic-Milacic, M, 2012-02-14
dbId	2122948
displayName	Activated NOTCH1 Transmits Signal to the Nucleus
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06
eventOf	[Pathway:R-HSA-1980143] Signaling by NOTCH1 - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:20089] Notch signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-1980039] NOTCH1 binds DLL1 - Homo sapiens [Reaction:R-HSA-1980041] NOTCH1 binds DLL4 - Homo sapiens [Reaction:R-HSA-1980042] NOTCH1 binds JAG1 - Homo sapiens [Reaction:R-HSA-1980044] NOTCH1 binds JAG2 - Homo sapiens [Reaction:R-HSA-1980074] Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 - Homo sapiens [Reaction:R-HSA-157632] Complex of NOTCH1 with its ligand is cleaved to produce NEXT1 - Homo sapiens [Reaction:R-HSA-157353] NEXT1 is cleaved to produce NICD1 - Homo sapiens [Reaction:R-HSA-157926] NICD1 traffics to nucleus - Homo sapiens [Reaction:R-HSA-1980122] DTX binds NOTCH1 - Homo sapiens [Reaction:R-HSA-373706] Contactin-1 (CNTN1) binds NOTCH1 - Homo sapiens [BlackBoxEvent:R-HSA-1980109] Cleavage of CNTN1:NOTCH1 complex releases NICD1 - Homo sapiens [Reaction:R-HSA-1912398] NOTCH1 binds DNER - Homo sapiens [BlackBoxEvent:R-HSA-1980112] Cleavage of DNER:NOTCH1 complex releases NICD1 - Homo sapiens [Reaction:R-HSA-1980123] DTX recruits beta-arrestin (ARRB) to NOTCH - Homo sapiens [BlackBoxEvent:R-HSA-1980118] ARRB mediates NOTCH1 ubiquitination - Homo sapiens [Reaction:R-HSA-1980125] ITCH binds DTX - Homo sapiens [Reaction:R-HSA-1912357] ITCH ubiquitinates DTX - Homo sapiens [Reaction:R-HSA-1980138] NOTCH1 binds DLL/JAG ligand in cis - Homo sapiens [Reaction:R-HSA-1980130] NOTCH1 binds DLK1 - Homo sapiens [Reaction:R-HSA-1980128] NOTCH1 associates with negative regulators NUMB and ITCH - Homo sapiens [Reaction:R-HSA-1912386] Ubiquitination of NOTCH1 by ITCH in the absence of ligand - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2016-12-21
literatureReference	[LiteratureReference:2046385] Localization of the delta-like-1-binding site in human Notch-1 and its modulation by calcium affinity [LiteratureReference:186662] Delta-1 activation of notch-1 signaling results in HES-1 transactivation [LiteratureReference:2050621] The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis [LiteratureReference:2053957] The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1 [LiteratureReference:157224] Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor [LiteratureReference:2053968] Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors [LiteratureReference:2050520] Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1 [LiteratureReference:1602210] An obligatory role of mind bomb-1 in notch signaling of mammalian development [LiteratureReference:1602191] Mind bomb-2 is an E3 ligase for Notch ligand [LiteratureReference:2084252] Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1 [LiteratureReference:1602202] Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta [LiteratureReference:208133] Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta [LiteratureReference:2084254] Neuralized-like 1 (Neurl1) targeted to the plasma membrane by N-myristoylation regulates the Notch ligand Jagged1 [LiteratureReference:2059852] Metalloprotease ADAM10 is required for Notch1 site 2 cleavage [LiteratureReference:157210] A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE [LiteratureReference:2059841] The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts [LiteratureReference:2059844] Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis [LiteratureReference:163904] A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain [LiteratureReference:163911] Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain [LiteratureReference:163903] Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1 [LiteratureReference:373542] F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation [LiteratureReference:1890294] DNER acts as a neuron-specific Notch ligand during Bergmann glial development [LiteratureReference:1602194] Human deltex is a conserved regulator of Notch signalling [LiteratureReference:1602199] Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis [LiteratureReference:1911367] Regulation of Notch signalling by non-visual beta-arrestin [LiteratureReference:1602188] Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains [LiteratureReference:2076204] Cis-interactions between Notch and Delta generate mutually exclusive signalling states [LiteratureReference:1602201] dlk acts as a negative regulator of Notch1 activation through interactions with specific EGF-like repeats [LiteratureReference:1602211] The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila [LiteratureReference:2077480] Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells [LiteratureReference:1602206] Numb regulates post-endocytic trafficking and degradation of Notch1 [LiteratureReference:1602207] AIP4/Itch regulates Notch receptor degradation in the absence of ligand
maxDepth	2
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Activated NOTCH1 Transmits Signal to the Nucleus
orthologousEvent	[Pathway:R-CFA-2122948] Activated NOTCH1 Transmits Signal to the Nucleus - Canis familiaris [Pathway:R-DME-2122948] Activated NOTCH1 Transmits Signal to the Nucleus - Drosophila melanogaster [Pathway:R-GGA-2122948] Activated NOTCH1 Transmits Signal to the Nucleus - Gallus gallus [Pathway:R-XTR-2122948] Activated NOTCH1 Transmits Signal to the Nucleus - Xenopus tropicalis [Pathway:R-DRE-2122948] Activated NOTCH1 Transmits Signal to the Nucleus - Danio rerio [Pathway:R-SSC-2122948] Activated NOTCH1 Transmits Signal to the Nucleus - Sus scrofa [Pathway:R-BTA-2122948] Activated NOTCH1 Transmits Signal to the Nucleus - Bos taurus [Pathway:R-RNO-2122948] Activated NOTCH1 Transmits Signal to the Nucleus - Rattus norvegicus [Pathway:R-MMU-2122948] Activated NOTCH1 Transmits Signal to the Nucleus - Mus musculus
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2121207] Haw, R, 2012-02-06
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2122948
summation	[Summation:2122957] Mature NOTCH1 heterodimer on the cell surface is activated b...
updateTrackers	[UpdateTracker:9787683] Update Tracker - [Pathway:2122948] Activated NOTCH1 Transmits Signal to the Nucleus - v44:[updateContainedRLE] [UpdateTracker:9782145] Update Tracker - [Pathway:2122948] Activated NOTCH1 Transmits Signal to the Nucleus - v59:[updateContainedRLE] [UpdateTracker:9788660] Update Tracker - [Pathway:2122948] Activated NOTCH1 Transmits Signal to the Nucleus - v41:[updateContainedRLE]

Referrals

(hasEvent)

[Pathway:R-HSA-1980143] Signaling by NOTCH1

(updatedInstance)

[UpdateTracker:9787683] Update Tracker - [Pathway:2122948] Activated NOTCH1 Transmits Signal to the Nucleus - v44:[updateContainedRLE]
[UpdateTracker:9782145] Update Tracker - [Pathway:2122948] Activated NOTCH1 Transmits Signal to the Nucleus - v59:[updateContainedRLE]
[UpdateTracker:9788660] Update Tracker - [Pathway:2122948] Activated NOTCH1 Transmits Signal to the Nucleus - v41:[updateContainedRLE]

Cite Us!