Reactome | NOTCH1 binds JAG1

Schema > Reaction > Entries

NOTCH1 binds JAG1 Show undefined attributes

authored	[InstanceEdit:157021] Jassal, B, 2004-12-15 13:08:03
category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:1980043] Orlic-Milacic, M, 2011-11-08
dbId	1980042
deleted	[Deleted:2060817] Deletion of instance: 157020 [Deleted:5694729] Deletion of instance: 157645 [Deleted:5694726] Deletion of instance: 157083
diseaseReaction	[Reaction:R-HSA-2691226] NOTCH1 HD domain mutants bind JAG1 - Homo sapiens [Reaction:R-HSA-2900743] NOTCH1 HD+PEST domain mutants bind JAG1 - Homo sapiens [Reaction:R-HSA-2768999] NOTCH1 PEST domain mutants bind JAG1 - Homo sapiens [FailedReaction:R-HSA-2660822] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG1 - Homo sapiens
displayName	NOTCH1 binds JAG1
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06
entityOnOtherCell	[EntityWithAccessionedSequence:R-HSA-157098] JAG1 [plasma membrane] - Homo sapiens
eventOf	[Pathway:R-HSA-2122948] Activated NOTCH1 Transmits Signal to the Nucleus - Homo sapiens
followingEvent	[Reaction:R-HSA-1980074] Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 - Homo sapiens
inferredFrom	[Reaction:R-MMU-2053963] Notch1 binds Jag1 - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-157098] JAG1 [plasma membrane] [Complex:R-HSA-157027] NOTCH1 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:2050621] The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis [LiteratureReference:2053957] The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NOTCH1 binds JAG1
output	[Complex:R-HSA-157008] JAG1:NOTCH1 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-1912382] Mature NOTCH heterodimer traffics to the plasma membrane - Homo sapiens
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:165114] Joutel, A, 2004-12-15 [InstanceEdit:2121207] Haw, R, 2012-02-06
revised	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1980042
summation	[Summation:2053966] NOTCH1 is activated by JAG1 ligand expressed on a neighborin...

Referrals

(replacementInstances)	[Deleted:2060817] Deletion of instance: 157020 [Deleted:5694729] Deletion of instance: 157645 [Deleted:5694726] Deletion of instance: 157083
(normalReaction)	[Reaction:R-HSA-2691226] NOTCH1 HD domain mutants bind JAG1 [Reaction:R-HSA-2900743] NOTCH1 HD+PEST domain mutants bind JAG1 [Reaction:R-HSA-2768999] NOTCH1 PEST domain mutants bind JAG1 [FailedReaction:R-HSA-2660822] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG1
(hasEvent)	[Pathway:R-HSA-2122948] Activated NOTCH1 Transmits Signal to the Nucleus
(precedingEvent)	[Reaction:R-HSA-1980074] Ubiquitination of DLL/JAG ligands upon binding to NOTCH1
(inferredTo)	[Reaction:R-MMU-2053963] Notch1 binds Jag1