Reactome | ITCH ubiquitinates DTX

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ITCH ubiquitinates DTX Show undefined attributes

authored	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
catalystActivity	[CatalystActivity:1604455] ubiquitin-protein transferase activity of DTX:ITCH [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1912358] Orlic-Milacic, M, 2011-11-01
dbId	1912357
displayName	ITCH ubiquitinates DTX
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06
eventOf	[Pathway:R-HSA-2122948] Activated NOTCH1 Transmits Signal to the Nucleus - Homo sapiens
input	[Complex:R-HSA-1604453] DTX:ITCH [cytosol] [DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1602188] Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	ITCH ubiquitinates DTX
orthologousEvent	[Reaction:R-CFA-1912357] ITCH ubiquitinates DTX - Canis familiaris [Reaction:R-DME-1912357] ITCH ubiquitinates DTX - Drosophila melanogaster [Reaction:R-GGA-1912357] ITCH ubiquitinates DTX - Gallus gallus [Reaction:R-XTR-1912357] ITCH ubiquitinates DTX - Xenopus tropicalis [Reaction:R-DRE-1912357] ITCH ubiquitinates DTX - Danio rerio [Reaction:R-SSC-1912357] ITCH ubiquitinates DTX - Sus scrofa [Reaction:R-BTA-1912357] ITCH ubiquitinates DTX - Bos taurus [Reaction:R-RNO-1912357] ITCH ubiquitinates DTX - Rattus norvegicus [Reaction:R-MMU-1912357] ITCH ubiquitinates DTX - Mus musculus
output	[Complex:R-HSA-1911536] Ub-DTX:ITCH [cytosol]
precedingEvent	[Reaction:R-HSA-1980125] ITCH binds DTX - Homo sapiens
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2121207] Haw, R, 2012-02-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1912357
summation	[Summation:2066012] ITCH ubiquitinates DTX, targeting it for degradation.
updateTrackers	[UpdateTracker:9782136] Update Tracker - [Reaction:1912357] ITCH ubiquitinates DTX - v59:[add_removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9782136] Update Tracker - [Reaction:1912357] ITCH ubiquitinates DTX - v59:[add_removeLiteratureReference]
(hasEvent)	[Pathway:R-HSA-2122948] Activated NOTCH1 Transmits Signal to the Nucleus