Reactome | Cleavage of CNTN1:NOTCH1 complex releases NICD1

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Cleavage of CNTN1:NOTCH1 complex releases NICD1 Show undefined attributes

authored	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:1980111] Orlic-Milacic, M, 2011-11-08
dbId	1980109
displayName	Cleavage of CNTN1:NOTCH1 complex releases NICD1
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06
entityOnOtherCell	[EntityWithAccessionedSequence:R-HSA-373622] CNTN1 [plasma membrane] - Homo sapiens
eventOf	[Pathway:R-HSA-2122948] Activated NOTCH1 Transmits Signal to the Nucleus - Homo sapiens
inferredFrom	[BlackBoxEvent:R-NUL-2065902] Gamma secretase complex cleaves Cntn1-actived Notch1 - Mus musculus
input	[Complex:R-HSA-373658] CNTN1:NOTCH1:DTX [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:373542] F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Cleavage of CNTN1:NOTCH1 complex releases NICD1
output	[Complex:R-HSA-1911468] NICD1:DTX [cytosol]
precedingEvent	[Reaction:R-HSA-373706] Contactin-1 (CNTN1) binds NOTCH1 - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-1980110] Positive regulation by 'gamma-secretase complex [plasma membrane]'
regulationReference	[RegulationReference:9641411] Positive regulation by 'gamma-secretase complex [plasma membrane]' F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2121207] Haw, R, 2012-02-06
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1980109
summation	[Summation:2065910] Binding of NOTCH1 to CNTN1 (contactin-1) is followed by gamm...

Referrals

(hasEvent)	[Pathway:R-HSA-2122948] Activated NOTCH1 Transmits Signal to the Nucleus
(inferredTo)	[BlackBoxEvent:R-NUL-2065902] Gamma secretase complex cleaves Cntn1-actived Notch1

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