Reactome | NOTCH1 binds DLL4

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NOTCH1 binds DLL4 Show undefined attributes

authored	[InstanceEdit:157021] Jassal, B, 2004-12-15 13:08:03
category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:1980040] Orlic-Milacic, M, 2011-11-08
dbId	1980041
deleted	[Deleted:5694729] Deletion of instance: 157645 [Deleted:5694726] Deletion of instance: 157083
diseaseReaction	[Reaction:R-HSA-2691211] NOTCH1 HD domain mutants bind DLL4 - Homo sapiens [Reaction:R-HSA-2900747] NOTCH1 HD+PEST domain mutants bind DLL4 - Homo sapiens [Reaction:R-HSA-2769000] NOTCH1 PEST domain mutants bind DLL4 - Homo sapiens [FailedReaction:R-HSA-2660815] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL4 - Homo sapiens
displayName	NOTCH1 binds DLL4
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06
entityOnOtherCell	[EntityWithAccessionedSequence:R-HSA-158437] DLL4 [plasma membrane] - Homo sapiens
eventOf	[Pathway:R-HSA-2122948] Activated NOTCH1 Transmits Signal to the Nucleus - Homo sapiens
followingEvent	[Reaction:R-HSA-1980074] Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 - Homo sapiens
inferredFrom	[Reaction:R-MMU-2053938] Dll4 binds Notch1 - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-158437] DLL4 [plasma membrane] [DefinedSet:R-HSA-1911555] NOTCH1/Fringe-modified NOTCH1 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:2050621] The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis [LiteratureReference:2153441] Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment [LiteratureReference:2235046] Delta-like 4 is indispensable in thymic environment specific for T cell development
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NOTCH1 binds DLL4
output	[Complex:R-HSA-1911559] DLL4:NOTCH1 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-1912382] Mature NOTCH heterodimer traffics to the plasma membrane - Homo sapiens [BlackBoxEvent:R-HSA-1912379] Transport of fringe-modified NOTCH to plasma membrane - Homo sapiens
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:165114] Joutel, A, 2004-12-15 [InstanceEdit:2121207] Haw, R, 2012-02-06
revised	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1980041
summation	[Summation:2053943] NOTCH1 is activated by DLL4 ligand expressed on a neighborin...
updateTrackers	[UpdateTracker:9788589] Update Tracker - [Reaction:1980041] NOTCH1 binds DLL4 - v41:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788589] Update Tracker - [Reaction:1980041] NOTCH1 binds DLL4 - v41:[addLiteratureReference, modifyText]
(replacementInstances)	[Deleted:5694729] Deletion of instance: 157645 [Deleted:5694726] Deletion of instance: 157083
(normalReaction)	[Reaction:R-HSA-2691211] NOTCH1 HD domain mutants bind DLL4 [Reaction:R-HSA-2900747] NOTCH1 HD+PEST domain mutants bind DLL4 [Reaction:R-HSA-2769000] NOTCH1 PEST domain mutants bind DLL4 [FailedReaction:R-HSA-2660815] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL4
(hasEvent)	[Pathway:R-HSA-2122948] Activated NOTCH1 Transmits Signal to the Nucleus
(precedingEvent)	[Reaction:R-HSA-1980074] Ubiquitination of DLL/JAG ligands upon binding to NOTCH1
(inferredTo)	[Reaction:R-MMU-2053938] Dll4 binds Notch1