Reactome | ARRB mediates NOTCH1 ubiquitination

Schema > BlackBoxEvent > Entries

authored	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
catalystActivity	[CatalystActivity:69594] ubiquitin-protein transferase activity of Ubiquitin ligase [cytosol]
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:1980117] Orlic-Milacic, M, 2011-11-08
dbId	1980118
displayName	ARRB mediates NOTCH1 ubiquitination
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06
eventOf	[Pathway:R-HSA-2122948] Activated NOTCH1 Transmits Signal to the Nucleus - Homo sapiens
inferredFrom	[BlackBoxEvent:R-NUL-2071858] Kurtz promotes ubiquitination of Notch - Drosophila melanogaster
input	[Complex:R-HSA-1911487] NOTCH1:DTX:ARRB [plasma membrane] [DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:1911367] Regulation of Notch signalling by non-visual beta-arrestin
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ARRB mediates NOTCH1 ubiquitination
output	[Complex:R-HSA-1911542] Ub-NOTCH1:DTX:ARRB [plasma membrane]
precedingEvent	[Reaction:R-HSA-1980123] DTX recruits beta-arrestin (ARRB) to NOTCH - Homo sapiens
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2121207] Haw, R, 2012-02-06
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1980118
summation	[Summation:2071900] Ubiquitination of NOTCH1 mediated by DTX-recruited beta-arre...

(hasEvent)	[Pathway:R-HSA-2122948] Activated NOTCH1 Transmits Signal to the Nucleus
(inferredTo)	[BlackBoxEvent:R-NUL-2071858] Kurtz promotes ubiquitination of Notch

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