Reactome | NOTCH1 binds DLL1

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NOTCH1 binds DLL1 Show undefined attributes

authored	[InstanceEdit:157021] Jassal, B, 2004-12-15 13:08:03
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:1980037] Orlic-Milacic, M, 2011-11-08
dbId	1980039
deleted	[Deleted:5694729] Deletion of instance: 157645 [Deleted:5694726] Deletion of instance: 157083
diseaseReaction	[Reaction:R-HSA-2691219] NOTCH1 HD domain mutants bind DLL1 - Homo sapiens [Reaction:R-HSA-2900748] NOTCH1 HD+PEST domain mutants bind DLL1 - Homo sapiens [Reaction:R-HSA-2769008] NOTCH1 PEST domain mutants bind DLL1 - Homo sapiens [FailedReaction:R-HSA-2660819] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL1 - Homo sapiens
displayName	NOTCH1 binds DLL1
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06
entityOnOtherCell	[EntityWithAccessionedSequence:R-HSA-157089] DLL1 [plasma membrane] - Homo sapiens
eventOf	[Pathway:R-HSA-2122948] Activated NOTCH1 Transmits Signal to the Nucleus - Homo sapiens
followingEvent	[Reaction:R-HSA-1980074] Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 - Homo sapiens
inferredFrom	[Reaction:R-RNO-2050606] Dll1 binds Notch1 - Rattus norvegicus
input	[EntityWithAccessionedSequence:R-HSA-157089] DLL1 [plasma membrane] [DefinedSet:R-HSA-1911555] NOTCH1/Fringe-modified NOTCH1 [plasma membrane]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:2046385] Localization of the delta-like-1-binding site in human Notch-1 and its modulation by calcium affinity [LiteratureReference:186662] Delta-1 activation of notch-1 signaling results in HES-1 transactivation [LiteratureReference:2050520] Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NOTCH1 binds DLL1
output	[Complex:R-HSA-1911557] DLL1:NOTCH1 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-1912382] Mature NOTCH heterodimer traffics to the plasma membrane - Homo sapiens [BlackBoxEvent:R-HSA-1912379] Transport of fringe-modified NOTCH to plasma membrane - Homo sapiens
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:165114] Joutel, A, 2004-12-15 [InstanceEdit:2121207] Haw, R, 2012-02-06
revised	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1980039
summation	[Summation:1980038] The NOTCH1 receptor is activated by binding Delta-like 1 lig...
updateTrackers	[UpdateTracker:9787808] Update Tracker - [Reaction:1980039] NOTCH1 binds DLL1 - v44:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9787808] Update Tracker - [Reaction:1980039] NOTCH1 binds DLL1 - v44:[modifyText]
(replacementInstances)	[Deleted:5694729] Deletion of instance: 157645 [Deleted:5694726] Deletion of instance: 157083
(normalReaction)	[Reaction:R-HSA-2691219] NOTCH1 HD domain mutants bind DLL1 [Reaction:R-HSA-2900748] NOTCH1 HD+PEST domain mutants bind DLL1 [Reaction:R-HSA-2769008] NOTCH1 PEST domain mutants bind DLL1 [FailedReaction:R-HSA-2660819] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL1
(hasEvent)	[Pathway:R-HSA-2122948] Activated NOTCH1 Transmits Signal to the Nucleus
(precedingEvent)	[Reaction:R-HSA-1980074] Ubiquitination of DLL/JAG ligands upon binding to NOTCH1
(inferredTo)	[Reaction:R-RNO-2050606] Dll1 binds Notch1

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