Reactome | Activated NOTCH1 Transmits Signal to the Nucleus

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Activated NOTCH1 Transmits Signal to the Nucleus Show undefined attributes

compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10827377
displayName	Activated NOTCH1 Transmits Signal to the Nucleus
eventOf	[Pathway:R-GGA-1980143] Signaling by NOTCH1 - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:20089] Notch signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-GGA-1980044] NOTCH1 binds JAG2 - Gallus gallus [Reaction:R-GGA-1980122] DTX binds NOTCH1 - Gallus gallus [Reaction:R-GGA-1980125] ITCH binds DTX - Gallus gallus [Reaction:R-GGA-1912357] ITCH ubiquitinates DTX - Gallus gallus
inferredFrom	[Pathway:R-HSA-2122948] Activated NOTCH1 Transmits Signal to the Nucleus - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Activated NOTCH1 Transmits Signal to the Nucleus
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-2122948
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-1980143] Signaling by NOTCH1
(inferredTo)	[Pathway:R-HSA-2122948] Activated NOTCH1 Transmits Signal to the Nucleus

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