Reactome | AXIN is phosphorylated in the destruction complex

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AXIN is phosphorylated in the destruction complex Show undefined attributes

authored	[InstanceEdit:5229354] Rothfels, K, 2014-01-17
catalystActivity	[CatalystActivity:5229341] protein serine/threonine kinase activity of AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5229345] Rothfels, K, 2014-01-17
dbId	5229343
displayName	AXIN is phosphorylated in the destruction complex
edited	[InstanceEdit:5323556] Rothfels, K, 2014-02-15
eventOf	[Pathway:R-HSA-195253] Degradation of beta-catenin by the destruction complex - Homo sapiens
followingEvent	[Reaction:R-HSA-195304] Association of beta-catenin with the destruction complex - Homo sapiens
input	3 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-195250] AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5229342] Wnt stabilization of ?-catenin reveals principles for morphogen receptor-scaffold assemblies [LiteratureReference:3640789] Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin [LiteratureReference:208113] Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex [LiteratureReference:208242] A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression [LiteratureReference:5140717] An anti-Wnt5a antibody suppresses metastasis of gastric cancer cells in vivo by inhibiting receptor-mediated endocytosis [LiteratureReference:208273] Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability [LiteratureReference:4641111] Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex [LiteratureReference:3238089] The way Wnt works: Components and mechanism
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	AXIN is phosphorylated in the destruction complex
orthologousEvent	[Reaction:R-CEL-5229343] AXIN is phosphorylated in the destruction complex - Caenorhabditis elegans [Reaction:R-DME-5229343] AXIN is phosphorylated in the destruction complex - Drosophila melanogaster [Reaction:R-GGA-5229343] AXIN is phosphorylated in the destruction complex - Gallus gallus [Reaction:R-SSC-5229343] AXIN is phosphorylated in the destruction complex - Sus scrofa [Reaction:R-BTA-5229343] AXIN is phosphorylated in the destruction complex - Bos taurus [Reaction:R-CFA-5229343] AXIN is phosphorylated in the destruction complex - Canis familiaris [Reaction:R-RNO-5229343] AXIN is phosphorylated in the destruction complex - Rattus norvegicus [Reaction:R-MMU-5229343] AXIN is phosphorylated in the destruction complex - Mus musculus
output	3 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-3601577] p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
precedingEvent	[Reaction:R-HSA-195251] Assembly of the destruction complex - Homo sapiens
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22
revised	[InstanceEdit:5433076] Salahshor, S, 2014-05-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5229343
summation	[Summation:5229344] In the absence of WNT signal, AXIN is a phosphoprotein; cand...

Referrals

(hasEvent)	[Pathway:R-HSA-195253] Degradation of beta-catenin by the destruction complex
(precedingEvent)	[Reaction:R-HSA-195304] Association of beta-catenin with the destruction complex

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