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Degradation of beta-catenin by the destruction complex
Stable Identifier
R-HSA-195253
DOI
10.3180/REACT_11063.1
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
Degradation of beta-catenin by the destruction complex (Homo sapiens)
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The beta-catenin destruction complex plays a key role in the canonical Wnt signaling pathway. In the absence of Wnt signaling, this complex controls the levels of cytoplamic beta-catenin. Beta-catenin associates with and is phosphorylated by the destruction complex. Phosphorylated beta-catenin is recognized and ubiquitinated by the SCF-beta TrCP ubiquitin ligase complex and is subsequently degraded by the proteasome (reviewed in Kimelman and Xu, 2006).
Literature References
PubMed ID
Title
Journal
Year
17143292
beta-catenin destruction complex: insights and questions from a structural perspective
Kimelman, D
,
Xu, W
Oncogene
2006
Participants
Events
Expression of AMER1 gene
(Homo sapiens)
Expression of AXIN1 gene
(Homo sapiens)
APC is K63-polyubiquitinated
(Homo sapiens)
ZRANB1 binds APC
(Homo sapiens)
Assembly of the destruction complex
(Homo sapiens)
AXIN is phosphorylated in the destruction complex
(Homo sapiens)
Association of beta-catenin with the destruction complex
(Homo sapiens)
Beta-catenin phosphorylation cascade
(Homo sapiens)
Phosphorylation of APC component of the destruction complex
(Homo sapiens)
Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex
(Homo sapiens)
Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex
(Homo sapiens)
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)
(Homo sapiens)
Degradation of ubiquitinated beta catenin by the proteasome
(Homo sapiens)
Repression of WNT target genes
(Homo sapiens)
Participates
as an event of
Signaling by WNT (Homo sapiens)
Orthologous Events
Degradation of beta-catenin by the destruction complex (Bos taurus)
Degradation of beta-catenin by the destruction complex (Caenorhabditis elegans)
Degradation of beta-catenin by the destruction complex (Canis familiaris)
Degradation of beta-catenin by the destruction complex (Danio rerio)
Degradation of beta-catenin by the destruction complex (Drosophila melanogaster)
Degradation of beta-catenin by the destruction complex (Gallus gallus)
Degradation of beta-catenin by the destruction complex (Mus musculus)
Degradation of beta-catenin by the destruction complex (Rattus norvegicus)
Degradation of beta-catenin by the destruction complex (Sus scrofa)
Degradation of beta-catenin by the destruction complex (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000149
,
BIOMD0000000654
,
BIOMD0000000656
,
BIOMD0000000648
,
BIOMD0000000653
,
BIOMD0000000652
,
BIOMD0000000655
Authored
Kimelman, D (2007-04-03)
Reviewed
Pagano, M (2007-04-27)
Created
Matthews, L (2007-04-03)
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