Reactome | Degradation of beta-catenin by the destruction complex

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Degradation of beta-catenin by the destruction complex Show undefined attributes

created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10556807
displayName	Degradation of beta-catenin by the destruction complex
eventOf	[Pathway:R-SSC-195721] Signaling by WNT - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-SSC-6781905] ZRANB1 binds APC - Sus scrofa [Reaction:R-SSC-195251] Assembly of the destruction complex - Sus scrofa [Reaction:R-SSC-5229343] AXIN is phosphorylated in the destruction complex - Sus scrofa [Reaction:R-SSC-195304] Association of beta-catenin with the destruction complex - Sus scrofa [Pathway:R-SSC-196299] Beta-catenin phosphorylation cascade - Sus scrofa [Reaction:R-SSC-195275] Phosphorylation of APC component of the destruction complex - Sus scrofa [Reaction:R-SSC-195280] Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex - Sus scrofa [Reaction:R-SSC-2130286] Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) - Sus scrofa [Pathway:R-SSC-4641265] Repression of WNT target genes - Sus scrofa
inferredFrom	[Pathway:R-HSA-195253] Degradation of beta-catenin by the destruction complex - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Degradation of beta-catenin by the destruction complex
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-195253
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-195721] Signaling by WNT
(hasEncapsulatedEvent)	[Pathway:R-SSC-8878171] Transcriptional regulation by RUNX1 [Pathway:R-SSC-201681] TCF dependent signaling in response to WNT
(inferredTo)	[Pathway:R-HSA-195253] Degradation of beta-catenin by the destruction complex

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