Reactome | Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex

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Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex Show undefined attributes

category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:195272] Matthews, L, 2007-04-03 12:38:03
dbId	195280
displayName	Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex
edited	[InstanceEdit:195272] Matthews, L, 2007-04-03 12:38:03
eventOf	[Pathway:R-HSA-195253] Degradation of beta-catenin by the destruction complex - Homo sapiens
followingEvent	[Reaction:R-HSA-2130279] Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex - Homo sapiens
input	[Complex:R-HSA-195297] p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:196262] Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex
orthologousEvent	[Reaction:R-CEL-195280] Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex - Caenorhabditis elegans [Reaction:R-DME-195280] Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex - Drosophila melanogaster [Reaction:R-GGA-195280] Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex - Gallus gallus [Reaction:R-XTR-195280] Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex - Xenopus tropicalis [Reaction:R-DRE-195280] Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex - Danio rerio [Reaction:R-SSC-195280] Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex - Sus scrofa [Reaction:R-BTA-195280] Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex - Bos taurus [Reaction:R-CFA-195280] Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex - Canis familiaris [Reaction:R-RNO-195280] Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex - Rattus norvegicus [Reaction:R-MMU-195280] Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex - Mus musculus
output	[Complex:R-HSA-195322] p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol]
precedingEvent	[Reaction:R-HSA-195275] Phosphorylation of APC component of the destruction complex - Homo sapiens
releaseDate	2007-05-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:196987] Pagano, M, 2007-04-27 13:02:18
revised	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5433076] Salahshor, S, 2014-05-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-195280
summation	[Summation:195307] The phosphorylation of the 20 aa repeats in APC results in a...
updateTrackers	[UpdateTracker:9787304] Update Tracker - [Reaction:195280] Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex - v45:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9787304] Update Tracker - [Reaction:195280] Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex - v45:[modifyText]
(hasEvent)	[Pathway:R-HSA-195253] Degradation of beta-catenin by the destruction complex
(precedingEvent)	[Reaction:R-HSA-2130279] Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex