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Schema
>
Reaction
>
Entries
Association of beta-catenin with the destruction complex
Show undefined attributes
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category
binding
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:195272] Matthews, L, 2007-04-03 12:38:03
dbId
195304
displayName
Association of beta-catenin with the destruction complex
edited
[InstanceEdit:195272] Matthews, L, 2007-04-03 12:38:03
eventOf
[Pathway:R-HSA-195253] Degradation of beta-catenin by the destruction complex - Homo sapiens
followingEvent
[Reaction:R-HSA-195318] Phosphorylation of beta-catenin at Ser45 by CK1 alpha - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-448839] CTNNB1 [cytosol]
[Complex:R-HSA-3601577] p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:196262] Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function
maxDepth
1
modified
[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name
Association of beta-catenin with the destruction complex
orthologousEvent
[Reaction:R-CEL-195304] Association of beta-catenin with the destruction complex - Caenorhabditis elegans
[Reaction:R-DME-195304] Association of beta-catenin with the destruction complex - Drosophila melanogaster
[Reaction:R-GGA-195304] Association of beta-catenin with the destruction complex - Gallus gallus
[Reaction:R-XTR-195304] Association of beta-catenin with the destruction complex - Xenopus tropicalis
[Reaction:R-DRE-195304] Association of beta-catenin with the destruction complex - Danio rerio
[Reaction:R-SSC-195304] Association of beta-catenin with the destruction complex - Sus scrofa
[Reaction:R-BTA-195304] Association of beta-catenin with the destruction complex - Bos taurus
[Reaction:R-CFA-195304] Association of beta-catenin with the destruction complex - Canis familiaris
[Reaction:R-RNO-195304] Association of beta-catenin with the destruction complex - Rattus norvegicus
[Reaction:R-MMU-195304] Association of beta-catenin with the destruction complex - Mus musculus
output
[Complex:R-HSA-3601581] CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
precedingEvent
[Reaction:R-HSA-5229343] AXIN is phosphorylated in the destruction complex - Homo sapiens
releaseDate
2007-05-15
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:196987] Pagano, M, 2007-04-27 13:02:18
revised
[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22
[InstanceEdit:5433076] Salahshor, S, 2014-05-12
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-195304
summation
[Summation:195291] Beta-catenin associates with the destruction complex through...
updateTrackers
[UpdateTracker:9786723] Update Tracker - [Reaction:195304] Association of beta-catenin with the destruction complex - v48:[add_removeInput]
[UpdateTracker:9786866] Update Tracker - [Reaction:195304] Association of beta-catenin with the destruction complex - v47:[add_removeInput]
[UpdateTracker:9782351] Update Tracker - [Reaction:195304] Association of beta-catenin with the destruction complex - v59:[add_removeInput, add_removeOutput]
Referrals
(updatedInstance)
[UpdateTracker:9786723] Update Tracker - [Reaction:195304] Association of beta-catenin with the destruction complex - v48:[add_removeInput]
[UpdateTracker:9786866] Update Tracker - [Reaction:195304] Association of beta-catenin with the destruction complex - v47:[add_removeInput]
[UpdateTracker:9782351] Update Tracker - [Reaction:195304] Association of beta-catenin with the destruction complex - v59:[add_removeInput, add_removeOutput]
(hasEvent)
[Pathway:R-HSA-195253] Degradation of beta-catenin by the destruction complex
(precedingEvent)
[Reaction:R-HSA-195318] Phosphorylation of beta-catenin at Ser45 by CK1 alpha
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