Reactome | Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)

Schema > Reaction > Entries

Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) Show undefined attributes

authored	[InstanceEdit:195289] Kimelman, D, 2007-04-03 12:34:14
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2130285] Rothfels, K, 2012-02-21
dbId	2130286
displayName	Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)
edited	[InstanceEdit:195272] Matthews, L, 2007-04-03 12:38:03 [InstanceEdit:2130241] Rothfels, K, 2012-02-16
eventOf	[Pathway:R-HSA-195253] Degradation of beta-catenin by the destruction complex - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-2130282] Degradation of ubiquitinated beta catenin by the proteasome - Homo sapiens
input	[Complex:R-HSA-2130280] RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] 4 × [DefinedSet:R-HSA-113595] Ub [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:196256] Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)
orthologousEvent	[Reaction:R-CEL-2130286] Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) - Caenorhabditis elegans [Reaction:R-DME-2130286] Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) - Drosophila melanogaster [Reaction:R-GGA-2130286] Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) - Gallus gallus [Reaction:R-SSC-2130286] Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) - Sus scrofa [Reaction:R-BTA-2130286] Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) - Bos taurus [Reaction:R-CFA-2130286] Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) - Canis familiaris [Reaction:R-RNO-2130286] Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) - Rattus norvegicus [Reaction:R-MMU-2130286] Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) - Mus musculus
output	[Complex:R-HSA-2130284] ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol]
precedingEvent	[Reaction:R-HSA-2130279] Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex - Homo sapiens
releaseDate	2007-05-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:196987] Pagano, M, 2007-04-27 13:02:18
revised	[InstanceEdit:2130226] Angers, S, 2012-02-16 [InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5433076] Salahshor, S, 2014-05-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2130286
summation	[Summation:196291] Beta-catenin is ubiquitinated by the SCF-B-TrCP1 complex.

Referrals

(hasEvent)	[Pathway:R-HSA-195253] Degradation of beta-catenin by the destruction complex
(precedingEvent)	[BlackBoxEvent:R-HSA-2130282] Degradation of ubiquitinated beta catenin by the proteasome