Reactome | Repression of WNT target genes

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Repression of WNT target genes Show undefined attributes

authored	[InstanceEdit:4610796] Rothfels, K, 2013-09-23
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4641266] Rothfels, K, 2013-09-27
dbId	4641265
displayName	Repression of WNT target genes
doi	10.3180/REACT_228106.1
edited	[InstanceEdit:5358774] Matthews, Lisa, 2014-04-03
eventOf	[Pathway:R-HSA-195253] Degradation of beta-catenin by the destruction complex - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-8944352] TCF/LEF binds WNT promoters - Homo sapiens [Reaction:R-HSA-4641229] TLE oligomerizes - Homo sapiens [Reaction:R-HSA-8944349] TLE tetramers bind TCF/LEF at WNT promoters - Homo sapiens [Reaction:R-HSA-4641231] TLE recruits HDAC1 to WNT promoters - Homo sapiens [Reaction:R-HSA-4649028] TLE forms non-functional complexes with AES - Homo sapiens [Reaction:R-HSA-5334050] TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes - Homo sapiens [BlackBoxEvent:R-HSA-5229348] Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2016-12-21
literatureReference	[LiteratureReference:4641103] Groucho: a corepressor with instructive roles in development [LiteratureReference:3299512] All Tcf HMG box transcription factors interact with Groucho-related co-repressors [LiteratureReference:3299519] Groucho oligomerization is required for repression in vivo [LiteratureReference:3299523] Products of the grg (Groucho-related gene) family can dimerize through the amino-terminal Q domain [LiteratureReference:3299522] Groucho/TLE family proteins and transcriptional repression [LiteratureReference:4641114] AES/GRG5: more than just a dominant-negative TLE/GRG family member
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Repression of WNT target genes
orthologousEvent	[Pathway:R-CEL-4641265] Repression of WNT target genes - Caenorhabditis elegans [Pathway:R-DME-4641265] Repression of WNT target genes - Drosophila melanogaster [Pathway:R-GGA-4641265] Repression of WNT target genes - Gallus gallus [Pathway:R-XTR-4641265] Repression of WNT target genes - Xenopus tropicalis [Pathway:R-DRE-4641265] Repression of WNT target genes - Danio rerio [Pathway:R-SSC-4641265] Repression of WNT target genes - Sus scrofa [Pathway:R-BTA-4641265] Repression of WNT target genes - Bos taurus [Pathway:R-CFA-4641265] Repression of WNT target genes - Canis familiaris [Pathway:R-RNO-4641265] Repression of WNT target genes - Rattus norvegicus [Pathway:R-MMU-4641265] Repression of WNT target genes - Mus musculus
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-4641265
summation	[Summation:4641167] In the absence of a WNT signal, many WNT target genes are re...
updateTrackers	[UpdateTracker:9782057] Update Tracker - [Pathway:4641265] Repression of WNT target genes - v59:[addHasEvent, updateContainedRLE] [UpdateTracker:9786040] Update Tracker - [Pathway:4641265] Repression of WNT target genes - v50:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9782057] Update Tracker - [Pathway:4641265] Repression of WNT target genes - v59:[addHasEvent, updateContainedRLE] [UpdateTracker:9786040] Update Tracker - [Pathway:4641265] Repression of WNT target genes - v50:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-195253] Degradation of beta-catenin by the destruction complex

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