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Entries
Pre-NOTCH Transcription and Translation
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authored
[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
compartment
[Compartment:7660] nucleoplasm
[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created
[InstanceEdit:1912405] Orlic-Milacic, M, 2011-11-01
dbId
1912408
displayName
Pre-NOTCH Transcription and Translation
doi
10.3180/R-HSA-1912408.3
edited
[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10
[InstanceEdit:2121209] May, B, 2012-02-09
[InstanceEdit:2098673] D'Eustachio, P, 2012-02-06
[InstanceEdit:1609686] Jupe, S, 2011-09-27
[InstanceEdit:2121211] Gillespie, ME, 2012-02-09
[InstanceEdit:2251519] D'Eustachio, P, 2012-05-15
[InstanceEdit:9027556] Orlic-Milacic, Marija, 2017-11-02
eventOf
[Pathway:R-HSA-1912422] Pre-NOTCH Expression and Processing - Homo sapiens
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-4395227] CCND1:CREBBP binds NOTCH1 promoter - Homo sapiens
[Reaction:R-HSA-4395231] E2F1/3:DP1/2 binds NOTCH1 promoter - Homo sapiens
[BlackBoxEvent:R-HSA-1912416] NOTCH1 gene transcription - Homo sapiens
[BlackBoxEvent:R-HSA-1912407] NOTCH2 gene transcription - Homo sapiens
[Reaction:R-HSA-9017835] NOTCH1 coactivator complex binds NOTCH3 gene - Homo sapiens
[Reaction:R-HSA-9021357] PRKCI phosphorylates ELF3 - Homo sapiens
[Reaction:R-HSA-9021364] ELF3 binds NOTCH3 gene promoter - Homo sapiens
[BlackBoxEvent:R-HSA-1912415] NOTCH3 gene transcription - Homo sapiens
[BlackBoxEvent:R-HSA-1912401] NOTCH4 gene transcription - Homo sapiens
[Reaction:R-HSA-4395236] TP53 binds promoters of MIR34 genes - Homo sapiens
[BlackBoxEvent:R-HSA-1912406] p53 positively regulates transcription of MIR34 microRNAs - Homo sapiens
[Reaction:R-HSA-1606682] MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA - Homo sapiens
[Reaction:R-HSA-1912363] MIR200B/C microRNAs bind NOTCH1 mRNA - Homo sapiens
[Reaction:R-HSA-1606561] MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA - Homo sapiens
[Reaction:R-HSA-1912367] MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA - Homo sapiens
[Reaction:R-HSA-1912362] MIR150 microRNA binds 3'UTR of NOTCH3 mRNA - Homo sapiens
[Reaction:R-HSA-1912366] MIR206 microRNA binds 3'UTR of NOTCH3 mRNA - Homo sapiens
[Reaction:R-HSA-1912364] MIR181C microRNA binds 3'UTR of NOTCH4 mRNA - Homo sapiens
[Reaction:R-HSA-1912368] MIR302A microRNA binds 3'UTR of NOTCH4 mRNA - Homo sapiens
[BlackBoxEvent:R-HSA-1912412] NOTCH1 mRNA translation controlled by miRNAs - Homo sapiens
[BlackBoxEvent:R-HSA-1912413] NOTCH2 mRNA translation controlled by miRNAs - Homo sapiens
[BlackBoxEvent:R-HSA-1912409] NOTCH3 mRNA translation controlled by miRNAs - Homo sapiens
[BlackBoxEvent:R-HSA-1912410] NOTCH4 mRNA translation controlled by miRNAs - Homo sapiens
[Reaction:R-HSA-9604703] RUNX1 binds NOTCH4 gene - Homo sapiens
[BlackBoxEvent:R-HSA-9604719] NOTCH4 gene transcription is inhibited by RUNX1 - Homo sapiens
[Reaction:R-HSA-9604834] SIRT6 binds to acetylated histones at NOTCH1 and NOTCH4 gene promoters - Homo sapiens
[Reaction:R-HSA-9604829] SIRT6 deacetylates histones at NOTCH1 and NOTCH4 gene promoters - Homo sapiens
[BlackBoxEvent:R-HSA-9604831] NOTCH1 and NOTCH4 gene transcription is inhibited by SIRT6 - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:2025693] TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
[LiteratureReference:157153] A homolog of Drosophila Notch expressed during mammalian development
[LiteratureReference:2152310] Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development
[LiteratureReference:2025782] The human NOTCH1, 2, and 3 genes are located at chromosome positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of neoplasia-associated translocation
[LiteratureReference:2025785] Notch-1 and Notch-2 exhibit unique patterns of expression in human B-lineage cells
[LiteratureReference:2025784] NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway
[LiteratureReference:2025819] Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia
[LiteratureReference:2025826] Cloning, characterization, and the complete 56.8-kilobase DNA sequence of the human NOTCH4 gene
[LiteratureReference:1606683] Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
[LiteratureReference:1606695] Transcriptional activation of miR-34a contributes to p53-mediated apoptosis
[LiteratureReference:1888218] A microRNA component of the p53 tumour suppressor network
[LiteratureReference:1890327] MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth
[LiteratureReference:1606697] MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes
[LiteratureReference:1606693] MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells
[LiteratureReference:1606696] MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells
[LiteratureReference:1888217] Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells
[LiteratureReference:1606546] Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway
[LiteratureReference:1892027] Modulation of microRNA expression in human T-cell development: targeting of NOTCH3 by miR-150
[LiteratureReference:1890323] MicroRNA-206 targets notch3, activates apoptosis, and inhibits tumor cell migration and focus formation
[LiteratureReference:1890316] Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis
[LiteratureReference:1890304] Epigenetically reprogramming metastatic tumor cells with an embryonic microenvironment
[LiteratureReference:1602198] Ca(2+)-ATPase function is required for intracellular trafficking of the Notch receptor in Drosophila
modified
[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name
Pre-NOTCH Transcription and Translation
orthologousEvent
[Pathway:R-CEL-1912408] Pre-NOTCH Transcription and Translation - Caenorhabditis elegans
[Pathway:R-GGA-1912408] Pre-NOTCH Transcription and Translation - Gallus gallus
[Pathway:R-SSC-1912408] Pre-NOTCH Transcription and Translation - Sus scrofa
[Pathway:R-BTA-1912408] Pre-NOTCH Transcription and Translation - Bos taurus
[Pathway:R-CFA-1912408] Pre-NOTCH Transcription and Translation - Canis familiaris
[Pathway:R-RNO-1912408] Pre-NOTCH Transcription and Translation - Rattus norvegicus
[Pathway:R-MMU-1912408] Pre-NOTCH Transcription and Translation - Mus musculus
releaseDate
2012-03-13
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2121207] Haw, R, 2012-02-06
[InstanceEdit:2252619] Haw, R, 2012-05-17
[InstanceEdit:9027525] Haw, Robin, 2017-10-30
[InstanceEdit:9608066] Haw, Robin, 2018-05-01
revised
[InstanceEdit:2252620] Egan, SE, Orlic-Milacic, M, 2012-05-14
[InstanceEdit:9021699] Orlic-Milacic, Marija, 2017-09-20
[InstanceEdit:9604946] Orlic-Milacic, Marija, 2018-04-05
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-1912408
summation
[Summation:2032338] In humans, the NOTCH protein family has four members: NOTCH1...
Referrals
(hasEvent)
[Pathway:R-HSA-1912422] Pre-NOTCH Expression and Processing
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