Reactome | Pre-NOTCH Transcription and Translation

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Pre-NOTCH Transcription and Translation Show undefined attributes

authored	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:1912405] Orlic-Milacic, M, 2011-11-01
dbId	1912408
displayName	Pre-NOTCH Transcription and Translation
doi	10.3180/R-HSA-1912408.3
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2121209] May, B, 2012-02-09 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06 [InstanceEdit:1609686] Jupe, S, 2011-09-27 [InstanceEdit:2121211] Gillespie, ME, 2012-02-09 [InstanceEdit:2251519] D'Eustachio, P, 2012-05-15 [InstanceEdit:9027556] Orlic-Milacic, Marija, 2017-11-02 [InstanceEdit:9925757] Orlic-Milacic, Marija, 2024-10-23
eventOf	[Pathway:R-HSA-1912422] Pre-NOTCH Expression and Processing - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-4395227] CCND1:CREBBP binds NOTCH1 promoter - Homo sapiens [Reaction:R-HSA-4395231] E2F1/3:DP1/2 binds NOTCH1 promoter - Homo sapiens [BlackBoxEvent:R-HSA-1912416] NOTCH1 gene transcription - Homo sapiens [BlackBoxEvent:R-HSA-1912407] NOTCH2 gene transcription - Homo sapiens [Reaction:R-HSA-9017835] NOTCH1 coactivator complex binds NOTCH3 gene - Homo sapiens [Reaction:R-HSA-9021357] PRKCI phosphorylates ELF3 - Homo sapiens [Reaction:R-HSA-9021364] ELF3 binds NOTCH3 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-1912415] NOTCH3 gene transcription - Homo sapiens [BlackBoxEvent:R-HSA-1912401] NOTCH4 gene transcription - Homo sapiens [Reaction:R-HSA-4395236] TP53 binds promoters of MIR34 genes - Homo sapiens [BlackBoxEvent:R-HSA-1912406] p53 positively regulates transcription of MIR34 microRNAs - Homo sapiens [Reaction:R-HSA-1606682] MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA - Homo sapiens [Reaction:R-HSA-1912363] MIR200B/C microRNAs bind NOTCH1 mRNA - Homo sapiens [Reaction:R-HSA-1606561] MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA - Homo sapiens [Reaction:R-HSA-1912367] MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA - Homo sapiens [Reaction:R-HSA-1912362] MIR150 microRNA binds 3'UTR of NOTCH3 mRNA - Homo sapiens [Reaction:R-HSA-1912366] MIR206 microRNA binds 3'UTR of NOTCH3 mRNA - Homo sapiens [Reaction:R-HSA-1912364] MIR181C microRNA binds 3'UTR of NOTCH4 mRNA - Homo sapiens [Reaction:R-HSA-1912368] MIR302A microRNA binds 3'UTR of NOTCH4 mRNA - Homo sapiens [BlackBoxEvent:R-HSA-1912412] NOTCH1 mRNA translation controlled by miRNAs - Homo sapiens [BlackBoxEvent:R-HSA-1912413] NOTCH2 mRNA translation controlled by miRNAs - Homo sapiens [BlackBoxEvent:R-HSA-1912409] NOTCH3 mRNA translation controlled by miRNAs - Homo sapiens [BlackBoxEvent:R-HSA-1912410] NOTCH4 mRNA translation controlled by miRNAs - Homo sapiens [Reaction:R-HSA-9604703] RUNX1 binds NOTCH4 gene - Homo sapiens [BlackBoxEvent:R-HSA-9604719] NOTCH4 gene transcription is inhibited by RUNX1 - Homo sapiens [Reaction:R-HSA-9604834] SIRT6 binds to acetylated histones at NOTCH1 and NOTCH4 gene promoters - Homo sapiens [Reaction:R-HSA-9604829] SIRT6 deacetylates histones at NOTCH1 and NOTCH4 gene promoters - Homo sapiens [BlackBoxEvent:R-HSA-9604831] NOTCH1 and NOTCH4 gene transcription is inhibited by SIRT6 - Homo sapiens [Pathway:R-HSA-9911233] Expression of NOTCH2NL genes - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2018-06-13
literatureReference	[LiteratureReference:2025693] TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms [LiteratureReference:157153] A homolog of Drosophila Notch expressed during mammalian development [LiteratureReference:2152310] Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development [LiteratureReference:2025782] The human NOTCH1, 2, and 3 genes are located at chromosome positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of neoplasia-associated translocation [LiteratureReference:2025785] Notch-1 and Notch-2 exhibit unique patterns of expression in human B-lineage cells [LiteratureReference:2025784] NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway [LiteratureReference:2025819] Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia [LiteratureReference:2025826] Cloning, characterization, and the complete 56.8-kilobase DNA sequence of the human NOTCH4 gene [LiteratureReference:1606683] Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis [LiteratureReference:1606695] Transcriptional activation of miR-34a contributes to p53-mediated apoptosis [LiteratureReference:1888218] A microRNA component of the p53 tumour suppressor network [LiteratureReference:1890327] MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth [LiteratureReference:1606697] MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes [LiteratureReference:1606693] MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells [LiteratureReference:1606696] MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells [LiteratureReference:1888217] Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells [LiteratureReference:1606546] Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway [LiteratureReference:1892027] Modulation of microRNA expression in human T-cell development: targeting of NOTCH3 by miR-150 [LiteratureReference:1890323] MicroRNA-206 targets notch3, activates apoptosis, and inhibits tumor cell migration and focus formation [LiteratureReference:1890316] Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis [LiteratureReference:1890304] Epigenetically reprogramming metastatic tumor cells with an embryonic microenvironment [LiteratureReference:1602198] Ca(2+)-ATPase function is required for intracellular trafficking of the Notch receptor in Drosophila
maxDepth	3
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Pre-NOTCH Transcription and Translation
orthologousEvent	[Pathway:R-CFA-1912408] Pre-NOTCH Transcription and Translation - Canis familiaris [Pathway:R-CEL-1912408] Pre-NOTCH Transcription and Translation - Caenorhabditis elegans [Pathway:R-GGA-1912408] Pre-NOTCH Transcription and Translation - Gallus gallus [Pathway:R-DRE-1912408] Pre-NOTCH Transcription and Translation - Danio rerio [Pathway:R-SSC-1912408] Pre-NOTCH Transcription and Translation - Sus scrofa [Pathway:R-BTA-1912408] Pre-NOTCH Transcription and Translation - Bos taurus [Pathway:R-RNO-1912408] Pre-NOTCH Transcription and Translation - Rattus norvegicus [Pathway:R-MMU-1912408] Pre-NOTCH Transcription and Translation - Mus musculus
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2121207] Haw, R, 2012-02-06 [InstanceEdit:2252619] Haw, R, 2012-05-17 [InstanceEdit:9027525] Haw, Robin, 2017-10-30 [InstanceEdit:9608066] Haw, Robin, 2018-05-01 [InstanceEdit:9925739] Heide, Michael, 2024-10-25
revised	[InstanceEdit:2252620] Egan, SE, Orlic-Milacic, M, 2012-05-14 [InstanceEdit:9021699] Orlic-Milacic, Marija, 2017-09-20 [InstanceEdit:9604946] Orlic-Milacic, Marija, 2018-04-05
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-1912408
summation	[Summation:2032338] In humans, the NOTCH protein family has four members: NOT...
updateTrackers	[UpdateTracker:9780280] Update Tracker - [Pathway:1912408] Pre-NOTCH Transcription and Translation - v63:[addHasEvent, updateContainedRLE] [UpdateTracker:9787002] Update Tracker - [Pathway:1912408] Pre-NOTCH Transcription and Translation - v46:[addHasEvent, updateContainedRLE] [UpdateTracker:9779657] Update Tracker - [Pathway:1912408] Pre-NOTCH Transcription and Translation - v65:[addHasEvent, modifyText] [UpdateTracker:9781928] Update Tracker - [Pathway:1912408] Pre-NOTCH Transcription and Translation - v60:[updateContainedRLE] [UpdateTracker:9928518] Update Tracker - [Pathway:1912408] Pre-NOTCH Transcription and Translation - v91:[modifyText, removeHasEvent] [UpdateTracker:9788573] Update Tracker - [Pathway:1912408] Pre-NOTCH Transcription and Translation - v41:[updateContainedRLE]

Referrals

(hasEvent)

[Pathway:R-HSA-1912422] Pre-NOTCH Expression and Processing

(updatedInstance)

[UpdateTracker:9780280] Update Tracker - [Pathway:1912408] Pre-NOTCH Transcription and Translation - v63:[addHasEvent, updateContainedRLE]
[UpdateTracker:9787002] Update Tracker - [Pathway:1912408] Pre-NOTCH Transcription and Translation - v46:[addHasEvent, updateContainedRLE]
[UpdateTracker:9779657] Update Tracker - [Pathway:1912408] Pre-NOTCH Transcription and Translation - v65:[addHasEvent, modifyText]
[UpdateTracker:9781928] Update Tracker - [Pathway:1912408] Pre-NOTCH Transcription and Translation - v60:[updateContainedRLE]
[UpdateTracker:9928518] Update Tracker - [Pathway:1912408] Pre-NOTCH Transcription and Translation - v91:[modifyText, removeHasEvent]
[UpdateTracker:9788573] Update Tracker - [Pathway:1912408] Pre-NOTCH Transcription and Translation - v41:[updateContainedRLE]

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