Reactome | p53 positively regulates transcription of MIR34 microRNAs

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p53 positively regulates transcription of MIR34 microRNAs Show undefined attributes

authored	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:1912405] Orlic-Milacic, M, 2011-11-01
dbId	1912406
displayName	p53 positively regulates transcription of MIR34 microRNAs
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06
eventOf	[Pathway:R-HSA-1912408] Pre-NOTCH Transcription and Translation - Homo sapiens
followingEvent	[Reaction:R-HSA-1912367] MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA - Homo sapiens [Reaction:R-HSA-1606682] MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA - Homo sapiens
input	[DefinedSet:R-HSA-1852586] MIR34 genes [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1606683] Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis [LiteratureReference:1606695] Transcriptional activation of miR-34a contributes to p53-mediated apoptosis [LiteratureReference:1888218] A microRNA component of the p53 tumour suppressor network [LiteratureReference:1890327] MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p53 positively regulates transcription of MIR34 microRNAs
output	[DefinedSet:R-HSA-1606685] miR-34 RISC [cytosol]
precedingEvent	[Reaction:R-HSA-4395236] TP53 binds promoters of MIR34 genes - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-2152394] Positive regulation by 'TP53 Tetramer:MIR34 genes [nucleoplasm]'
regulationReference	[RegulationReference:9642828] Positive regulation by 'TP53 Tetramer:MIR34 genes [nucleoplasm]' MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2121207] Haw, R, 2012-02-06
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1912406
summation	[Summation:1852632] Transcription of microRNA MIR34A is directly induced by the ...
updateTrackers	[UpdateTracker:9787107] Update Tracker - [BlackBoxEvent:1912406] p53 positively regulates transcription of MIR34 microRNAs - v46:[add_removeRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9787107] Update Tracker - [BlackBoxEvent:1912406] p53 positively regulates transcription of MIR34 microRNAs - v46:[add_removeRegulator]
(precedingEvent)	[Reaction:R-HSA-1912367] MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA [Reaction:R-HSA-1606682] MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA
(hasEvent)	[Pathway:R-HSA-1912408] Pre-NOTCH Transcription and Translation

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