Reactome | TP53 binds promoters of MIR34 genes

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TP53 binds promoters of MIR34 genes Show undefined attributes

authored	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4395235] Orlic-Milacic, M, 2013-08-22
dbId	4395236
displayName	TP53 binds promoters of MIR34 genes
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06
eventOf	[Pathway:R-HSA-1912408] Pre-NOTCH Transcription and Translation - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-1912406] p53 positively regulates transcription of MIR34 microRNAs - Homo sapiens
input	[DefinedSet:R-HSA-1852586] MIR34 genes [nucleoplasm] [Complex:R-HSA-3209194] TP53 Tetramer [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1606683] Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis [LiteratureReference:1606695] Transcriptional activation of miR-34a contributes to p53-mediated apoptosis [LiteratureReference:1888218] A microRNA component of the p53 tumour suppressor network [LiteratureReference:1890327] MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TP53 binds promoters of MIR34 genes
output	[Complex:R-HSA-4395237] TP53 Tetramer:MIR34 genes [nucleoplasm]
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2121207] Haw, R, 2012-02-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4395236
summation	[Summation:4395234] TP53 (p53) binds to the conserved p53 binding site located i...
updateTrackers	[UpdateTracker:9781938] Update Tracker - [Reaction:4395236] TP53 binds promoters of MIR34 genes - v60:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9781938] Update Tracker - [Reaction:4395236] TP53 binds promoters of MIR34 genes - v60:[modifyText]
(hasEvent)	[Pathway:R-HSA-1912408] Pre-NOTCH Transcription and Translation
(precedingEvent)	[BlackBoxEvent:R-HSA-1912406] p53 positively regulates transcription of MIR34 microRNAs

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