Reactome | NOTCH1 gene transcription

Schema > BlackBoxEvent > Entries

NOTCH1 gene transcription Show undefined attributes

authored	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:1912405] Orlic-Milacic, M, 2011-11-01
dbId	1912416
displayName	NOTCH1 gene transcription
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06 [InstanceEdit:2251519] D'Eustachio, P, 2012-05-15
eventOf	[Pathway:R-HSA-1912408] Pre-NOTCH Transcription and Translation - Homo sapiens
followingEvent	[Reaction:R-HSA-1606561] MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA - Homo sapiens [Reaction:R-HSA-1912363] MIR200B/C microRNAs bind NOTCH1 mRNA - Homo sapiens [Reaction:R-HSA-1606682] MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA - Homo sapiens [BlackBoxEvent:R-HSA-1912412] NOTCH1 mRNA translation controlled by miRNAs - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-2247925] Notch1 gene transcription - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-1911481] NOTCH1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:2025693] TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms [LiteratureReference:2105564] Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia [LiteratureReference:1485609] Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia [LiteratureReference:2152329] Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases [LiteratureReference:2152376] Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway [LiteratureReference:2247526] p53 regulates thymic Notch1 activation [LiteratureReference:2251506] Kr�ppel-like family of transcription factor 9, a differentiation-associated transcription factor, suppresses Notch1 signaling and inhibits glioblastoma-initiating stem cells [LiteratureReference:2251499] Jarid2 (Jumonji, AT rich interactive domain 2) regulates NOTCH1 expression via histone modification in the developing heart [LiteratureReference:2251500] Endothelial Jarid2/Jumonji is required for normal cardiac development and proper Notch1 expression [LiteratureReference:2251511] Differential control of Notch1 gene transcription by Klf4 and Sp3 transcription factors in normal versus cancer-derived keratinocytes [LiteratureReference:2251514] DeltaNp63alpha repression of the Notch1 gene supports the proliferative capacity of normal human keratinocytes and cervical cancer cells [LiteratureReference:2247540] Monitoring Notch1 activity in development: evidence for a feedback regulatory loop [LiteratureReference:2247943] Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NOTCH1 gene transcription
output	[EntityWithAccessionedSequence:R-HSA-1606559] NOTCH1 mRNA [cytosol]
precedingEvent	[Reaction:R-HSA-4395227] CCND1:CREBBP binds NOTCH1 promoter - Homo sapiens [Reaction:R-HSA-4395231] E2F1/3:DP1/2 binds NOTCH1 promoter - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-2247933] Positive gene expression regulation by 'NOTCH1 Coactivator Complex [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-2247947] Positive gene expression regulation by 'CCND1:CREBBP:NOTCH1 Gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-2248827] Positive gene expression regulation by 'E2F1/3:DP1/2:NOTCH1 Gene [nucleoplasm]'
regulationReference	[RegulationReference:9641408] Positive gene expression regulation by 'CCND1:CREBBP:NOTCH1 Gene [nucleoplasm]' Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen [RegulationReference:9641935] Positive gene expression regulation by 'NOTCH1 Coactivator Complex [nucleoplasm]' Monitoring Notch1 activity in development: evidence for a feedback regulatory loop [RegulationReference:9642722] Positive gene expression regulation by 'E2F1/3:DP1/2:NOTCH1 Gene [nucleoplasm]' Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2121207] Haw, R, 2012-02-06 [InstanceEdit:2252619] Haw, R, 2012-05-17
revised	[InstanceEdit:2252620] Egan, SE, Orlic-Milacic, M, 2012-05-14
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1912416
summation	[Summation:2025692] NOTCH1 was cloned as a chromosome 9 gene involved in translo...
updateTrackers	[UpdateTracker:9787174] Update Tracker - [BlackBoxEvent:1912416] NOTCH1 gene transcription - v46:[add_removeRegulator, modifyText] [UpdateTracker:9788512] Update Tracker - [BlackBoxEvent:1912416] NOTCH1 gene transcription - v41:[addLiteratureReference, addRegulator, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9787174] Update Tracker - [BlackBoxEvent:1912416] NOTCH1 gene transcription - v46:[add_removeRegulator, modifyText] [UpdateTracker:9788512] Update Tracker - [BlackBoxEvent:1912416] NOTCH1 gene transcription - v41:[addLiteratureReference, addRegulator, modifyText]
(hasEvent)	[Pathway:R-HSA-1912408] Pre-NOTCH Transcription and Translation
(precedingEvent)	[Reaction:R-HSA-1606561] MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA [Reaction:R-HSA-1912363] MIR200B/C microRNAs bind NOTCH1 mRNA [Reaction:R-HSA-1606682] MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA [BlackBoxEvent:R-HSA-1912412] NOTCH1 mRNA translation controlled by miRNAs
(inferredTo)	[BlackBoxEvent:R-MMU-2247925] Notch1 gene transcription

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