Reactome | NOTCH1 mRNA translation controlled by miRNAs

Schema > BlackBoxEvent > Entries

NOTCH1 mRNA translation controlled by miRNAs Show undefined attributes

authored	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:1912405] Orlic-Milacic, M, 2011-11-01
dbId	1912412
displayName	NOTCH1 mRNA translation controlled by miRNAs
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2121209] May, B, 2012-02-09 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06 [InstanceEdit:1609686] Jupe, S, 2011-09-27 [InstanceEdit:2121211] Gillespie, ME, 2012-02-09
eventOf	[Pathway:R-HSA-1912408] Pre-NOTCH Transcription and Translation - Homo sapiens
followingEvent	[Reaction:R-HSA-1912349] Fucosylation of Pre-NOTCH by POFUT1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-1606559] NOTCH1 mRNA [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1888217] Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells [LiteratureReference:1606697] MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes [LiteratureReference:1606696] MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells [LiteratureReference:1606546] Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway
maxDepth	1
modified	[InstanceEdit:9927655] Orlic-Milacic, Marija, 2024-11-08
name	NOTCH1 mRNA translation controlled by miRNAs
negativePrecedingEvent	[NegativePrecedingEvent:9927647] Negative relationship: NOTCH1 and NOTCH4 gene transcription is inhibited by SIRT6
output	[EntityWithAccessionedSequence:R-HSA-157024] Pre-NOTCH1 [endoplasmic reticulum membrane]
precedingEvent	[BlackBoxEvent:R-HSA-1912416] NOTCH1 gene transcription - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-1980087] Negative regulation by 'NOTCH1 mRNA:miR-200B/C RISC [cytosol]' [NegativeRegulation:R-HSA-1980089] Negative regulation by 'NOTCH1 mRNA:miR-34 RISC [cytosol]' [NegativeRegulation:R-HSA-1980095] Negative regulation by 'NOTCH1 mRNA:miR-449 RISC [cytosol]'
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2121207] Haw, R, 2012-02-06
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1912412
summation	[Summation:2029545] Translation of NOTCH1 mRNA is negatively regulated by microR...

Referrals

(hasEvent)	[Pathway:R-HSA-1912408] Pre-NOTCH Transcription and Translation
(precedingEvent)	[Reaction:R-HSA-1912349] Fucosylation of Pre-NOTCH by POFUT1