Reactome | NOTCH3 gene transcription

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NOTCH3 gene transcription Show undefined attributes

authored	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:1912405] Orlic-Milacic, M, 2011-11-01
dbId	1912415
displayName	NOTCH3 gene transcription
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06 [InstanceEdit:2251519] D'Eustachio, P, 2012-05-15 [InstanceEdit:9027527] Orlic-Milacic, Marija, 2017-11-02
eventOf	[Pathway:R-HSA-1912408] Pre-NOTCH Transcription and Translation - Homo sapiens
followingEvent	[Reaction:R-HSA-1912362] MIR150 microRNA binds 3'UTR of NOTCH3 mRNA - Homo sapiens [Reaction:R-HSA-1912366] MIR206 microRNA binds 3'UTR of NOTCH3 mRNA - Homo sapiens [BlackBoxEvent:R-HSA-1912409] NOTCH3 mRNA translation controlled by miRNAs - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:24616] positive regulation of Notch signaling pathway
input	[EntityWithAccessionedSequence:R-HSA-1911492] NOTCH3 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2025819] Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia [LiteratureReference:2248833] NOTCH3 expression is induced in mural cells through an autoregulatory loop that requires endothelial-expressed JAGGED1 [LiteratureReference:9017839] NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional network [LiteratureReference:9021358] Protein Kinase C? Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung Adenocarcinoma
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NOTCH3 gene transcription
output	[EntityWithAccessionedSequence:R-HSA-1911478] NOTCH3 mRNA [cytosol]
precedingEvent	[Reaction:R-HSA-9013631] NICD3 binds RBPJ and MAML in the nucleus - Homo sapiens [Reaction:R-HSA-9017835] NOTCH1 coactivator complex binds NOTCH3 gene - Homo sapiens [Reaction:R-HSA-9021364] ELF3 binds NOTCH3 gene promoter - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-2248835] Positive gene expression regulation by 'NOTCH3 coactivator complex [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-9017841] Positive gene expression regulation by 'NOTCH1 coactivator complex:NOTCH3 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-9021372] Positive gene expression regulation by 'p-S68-ELF3:NOTCH3 gene [nucleoplasm]'
regulationReference	[RegulationReference:9642729] Positive gene expression regulation by 'NOTCH3 coactivator complex [nucleoplasm]' NOTCH3 expression is induced in mural cells through an autoregulatory loop that requires endothelial-expressed JAGGED1 [RegulationReference:9642894] Positive gene expression regulation by 'p-S68-ELF3:NOTCH3 gene [nucleoplasm]' Protein Kinase C? Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung Adenocarcinoma [RegulationReference:9643030] Positive gene expression regulation by 'NOTCH1 coactivator complex:NOTCH3 gene [nucleoplasm]' NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional network
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2121207] Haw, R, 2012-02-06 [InstanceEdit:2252619] Haw, R, 2012-05-17 [InstanceEdit:9027525] Haw, Robin, 2017-10-30
revised	[InstanceEdit:2252620] Egan, SE, Orlic-Milacic, M, 2012-05-14 [InstanceEdit:9021699] Orlic-Milacic, Marija, 2017-09-20
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1912415
summation	[Summation:2025821] The NOTCH3 gene maps to human chromosome 19. NOTCH3 transcri...
updateTrackers	[UpdateTracker:9788713] Update Tracker - [BlackBoxEvent:1912415] NOTCH3 gene transcription - v41:[addLiteratureReference, addRegulator, modifyText] [UpdateTracker:9780338] Update Tracker - [BlackBoxEvent:1912415] NOTCH3 gene transcription - v63:[addLiteratureReference, addRegulator, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788713] Update Tracker - [BlackBoxEvent:1912415] NOTCH3 gene transcription - v41:[addLiteratureReference, addRegulator, modifyText] [UpdateTracker:9780338] Update Tracker - [BlackBoxEvent:1912415] NOTCH3 gene transcription - v63:[addLiteratureReference, addRegulator, modifyText]
(precedingEvent)	[Reaction:R-HSA-1912362] MIR150 microRNA binds 3'UTR of NOTCH3 mRNA [Reaction:R-HSA-1912366] MIR206 microRNA binds 3'UTR of NOTCH3 mRNA [BlackBoxEvent:R-HSA-1912409] NOTCH3 mRNA translation controlled by miRNAs
(hasEvent)	[Pathway:R-HSA-1912408] Pre-NOTCH Transcription and Translation

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