Reactome | NOTCH4 mRNA translation controlled by miRNAs

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NOTCH4 mRNA translation controlled by miRNAs Show undefined attributes

authored	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:1912405] Orlic-Milacic, M, 2011-11-01
dbId	1912410
displayName	NOTCH4 mRNA translation controlled by miRNAs
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2121209] May, B, 2012-02-09 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06 [InstanceEdit:1609686] Jupe, S, 2011-09-27 [InstanceEdit:2121211] Gillespie, ME, 2012-02-09
eventOf	[Pathway:R-HSA-1912408] Pre-NOTCH Transcription and Translation - Homo sapiens
followingEvent	[Reaction:R-HSA-1912349] Fucosylation of Pre-NOTCH by POFUT1 - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:161121] miRNA-mediated gene silencing by inhibition of translation
input	[EntityWithAccessionedSequence:R-HSA-1911475] NOTCH4 mRNA [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1890316] Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis [LiteratureReference:1890304] Epigenetically reprogramming metastatic tumor cells with an embryonic microenvironment
maxDepth	1
modified	[InstanceEdit:9927655] Orlic-Milacic, Marija, 2024-11-08
name	NOTCH4 mRNA translation controlled by miRNAs
negativePrecedingEvent	[NegativePrecedingEvent:9927652] Negative relationship: NOTCH1 and NOTCH4 gene transcription is inhibited by SIRT6 [NegativePrecedingEvent:9927653] Negative relationship: NOTCH4 gene transcription is inhibited by RUNX1
output	[EntityWithAccessionedSequence:R-HSA-157121] Pre-NOTCH4 [endoplasmic reticulum membrane]
precedingEvent	[BlackBoxEvent:R-HSA-1912401] NOTCH4 gene transcription - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-1980092] Negative regulation by 'NOTCH4 mRNA:miR-181C RISC [cytosol]' [NegativeRegulation:R-HSA-1980094] Negative regulation by 'NOTCH4 mRNA:miR-302A RISC [cytosol]'
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2121207] Haw, R, 2012-02-06
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1912410
summation	[Summation:2029547] Translation of NOTCH4 mRNA is negatively regulated by miR-18...

Referrals

(hasEvent)	[Pathway:R-HSA-1912408] Pre-NOTCH Transcription and Translation
(precedingEvent)	[Reaction:R-HSA-1912349] Fucosylation of Pre-NOTCH by POFUT1

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