Reactome | NOTCH4 gene transcription is inhibited by RUNX1

Schema > BlackBoxEvent > Entries

authored	[InstanceEdit:9604946] Orlic-Milacic, Marija, 2018-04-05
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9604721] Orlic-Milacic, Marija, 2018-04-05
dbId	9604719
displayName	NOTCH4 gene transcription is inhibited by RUNX1
edited	[InstanceEdit:9608067] Orlic-Milacic, Marija, 2018-05-09
eventOf	[Pathway:R-HSA-1912408] Pre-NOTCH Transcription and Translation - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:376439] negative regulation of gene expression
input	[EntityWithAccessionedSequence:R-HSA-1911501] NOTCH4 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9604710] Human NOTCH4 is a key target of RUNX1 in megakaryocytic differentiation
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NOTCH4 gene transcription is inhibited by RUNX1
output	[EntityWithAccessionedSequence:R-HSA-1911475] NOTCH4 mRNA [cytosol]
precedingEvent	[Reaction:R-HSA-9604703] RUNX1 binds NOTCH4 gene - Homo sapiens
regulatedBy	[NegativeGeneExpressionRegulation:9604723] Negative gene expression regulation by 'RUNX1:NOTCH4 gene [nucleoplasm]'
releaseDate	2018-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9608066] Haw, Robin, 2018-05-01
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9604719
summation	[Summation:9604720] RUNX1 binding to intron 29 of the NOTCH4 gene represses NOTC...

(hasEvent)	[Pathway:R-HSA-1912408] Pre-NOTCH Transcription and Translation
(precedingEvent)	[NegativePrecedingEvent:9927646] Negative relationship: NOTCH4 gene transcription is inhibited by RUNX1 [NegativePrecedingEvent:9927645] Negative relationship: NOTCH4 gene transcription is inhibited by RUNX1 [NegativePrecedingEvent:9927653] Negative relationship: NOTCH4 gene transcription is inhibited by RUNX1

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