Reactome | MAT1A multimers transfer Ado from ATP to L-Met

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MAT1A multimers transfer Ado from ATP to L-Met Show undefined attributes

authored	[InstanceEdit:351144] Gopinathrao, G, 2008-05-21 15:52:50
catalystActivity	[CatalystActivity:174380] methionine adenosyltransferase activity of MAT1A multimers [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:174378] Jassal, Bijay, 2006-02-17
crossReference	[DatabaseIdentifier:12667634] RHEA:21081 [DatabaseIdentifier:9929701] RHEA:21081
dbId	174391
diseaseReaction	[FailedReaction:R-HSA-5603087] Defective MAT1A does not transfer Ado from ATP to L-Met - Homo sapiens
displayName	MAT1A multimers transfer Ado from ATP to L-Met
edited	[InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48
eventOf	[Pathway:R-HSA-156581] Methylation - Homo sapiens [Pathway:R-HSA-1614635] Sulfur amino acid metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-8855062] SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy - Homo sapiens [Reaction:R-HSA-175976] TMT transfers CH3 from AdoMet to BME - Homo sapiens [Reaction:R-HSA-175987] NNMT transfers CH3 from AdoMet to PY - Homo sapiens [Reaction:R-HSA-351222] S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 - Homo sapiens [Reaction:R-HSA-175983] COMT transfer CH3 from AdoMet to 3,4DHBNZ - Homo sapiens [Reaction:R-HSA-158609] TPMT transfers CH3 from AdoMet to 6MP - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-174390] L-Met [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:353535] Regulation of mammalian liver methionine adenosyltransferase [LiteratureReference:353573] S-adenosylmethionine synthesis: molecular mechanisms and clinical implications
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	MAT1A multimers transfer Ado from ATP to L-Met ATP + H2O + L-methionine => diphosphate + phosphate + S-adenosyl-L-methionine SAM is sythesized from methionine's reaction with ATP
orthologousEvent	[Reaction:R-PFA-174391] MAT1A multimers transfer Ado from ATP to L-Met - Plasmodium falciparum [Reaction:R-SCE-174391] MAT1A multimers transfer Ado from ATP to L-Met - Saccharomyces cerevisiae [Reaction:R-DDI-174391] MAT1A multimers transfer Ado from ATP to L-Met - Dictyostelium discoideum [Reaction:R-DME-174391] MAT1A multimers transfer Ado from ATP to L-Met - Drosophila melanogaster [Reaction:R-MMU-174391] MAT1A multimers transfer Ado from ATP to L-Met - Mus musculus [Reaction:R-RNO-174391] MAT1A multimers transfer Ado from ATP to L-Met - Rattus norvegicus [Reaction:R-CEL-174391] MAT1A multimers transfer Ado from ATP to L-Met - Caenorhabditis elegans [Reaction:R-SPO-174391] MAT1A multimers transfer Ado from ATP to L-Met - Schizosaccharomyces pombe [Reaction:R-BTA-174391] MAT1A multimers transfer Ado from ATP to L-Met - Bos taurus [Reaction:R-GGA-174391] MAT1A multimers transfer Ado from ATP to L-Met - Gallus gallus [Reaction:R-XTR-174391] MAT1A multimers transfer Ado from ATP to L-Met - Xenopus tropicalis [Reaction:R-DRE-174391] MAT1A multimers transfer Ado from ATP to L-Met - Danio rerio [Reaction:R-SSC-174391] MAT1A multimers transfer Ado from ATP to L-Met - Sus scrofa [Reaction:R-CFA-174391] MAT1A multimers transfer Ado from ATP to L-Met - Canis familiaris
output	[SimpleEntity:R-ALL-71284] AdoMet [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-HSA-1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY - Homo sapiens [Reaction:R-HSA-5696838] BHMT2 tetramer transfers CH3 group from SMM to LHCYS - Homo sapiens [Reaction:R-HSA-174374] MTR transfers CH3 from MeCbl to HCYS - Homo sapiens [Reaction:R-HSA-1237102] Transamination of MOB to methionine - Homo sapiens
releaseDate	2008-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:377465] D'Eustachio, P, 2008-06-12 14:43:38
revised	[InstanceEdit:5602271] Jassal, Bijay, 2014-06-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-174391
summation	[Summation:179170] S-adenosylmethionine (AdoMet, SAM) is an essential metabolit...
updateTrackers	[UpdateTracker:9791854] Update Tracker - [Reaction:174391] MAT1A multimers transfer Ado from ATP to L-Met - v25:[addLiteratureReference, modifyText] [UpdateTracker:9786000] Update Tracker - [Reaction:174391] MAT1A multimers transfer Ado from ATP to L-Met - v50:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9791854] Update Tracker - [Reaction:174391] MAT1A multimers transfer Ado from ATP to L-Met - v25:[addLiteratureReference, modifyText] [UpdateTracker:9786000] Update Tracker - [Reaction:174391] MAT1A multimers transfer Ado from ATP to L-Met - v50:[modifyText]
(normalReaction)	[FailedReaction:R-HSA-5603087] Defective MAT1A does not transfer Ado from ATP to L-Met
(hasEvent)	[Pathway:R-HSA-156581] Methylation [Pathway:R-HSA-1614635] Sulfur amino acid metabolism
(precedingEvent)	[Reaction:R-HSA-8855062] SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy [Reaction:R-HSA-175976] TMT transfers CH3 from AdoMet to BME [Reaction:R-HSA-175987] NNMT transfers CH3 from AdoMet to PY [Reaction:R-HSA-351222] S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 [Reaction:R-HSA-158609] TPMT transfers CH3 from AdoMet to 6MP [Reaction:R-HSA-175983] COMT transfer CH3 from AdoMet to 3,4DHBNZ

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