Reactome | MAT1A multimers transfer Ado from ATP to L-Met

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MAT1A multimers transfer Ado from ATP to L-Met Show undefined attributes

catalystActivity	[CatalystActivity:10571723] methionine adenosyltransferase activity of MAT1A multimers [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10571725
displayName	MAT1A multimers transfer Ado from ATP to L-Met
eventOf	[Pathway:R-DRE-156581] Methylation - Danio rerio [Pathway:R-DRE-1614635] Sulfur amino acid metabolism - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-8855062] SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy - Danio rerio [Reaction:R-DRE-351222] S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 - Danio rerio [Reaction:R-DRE-175987] NNMT transfers CH3 from AdoMet to PY - Danio rerio [Reaction:R-DRE-175983] COMT transfer CH3 from AdoMet to 3,4DHBNZ - Danio rerio [Reaction:R-DRE-158609] TPMT transfers CH3 from AdoMet to 6MP - Danio rerio
inferredFrom	[Reaction:R-HSA-174391] MAT1A multimers transfer Ado from ATP to L-Met - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-174390] L-Met [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	MAT1A multimers transfer Ado from ATP to L-Met ATP + H2O + L-methionine => diphosphate + phosphate + S-adenosyl-L-methionine SAM is sythesized from methionine's reaction with ATP
output	[SimpleEntity:R-ALL-71284] AdoMet [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-DRE-1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY - Danio rerio [Reaction:R-DRE-5696838] BHMT2 tetramer transfers CH3 group from SMM to LHCYS - Danio rerio [Reaction:R-DRE-174374] MTR transfers CH3 from MeCbl to HCYS - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-174391
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-156581] Methylation [Pathway:R-DRE-1614635] Sulfur amino acid metabolism
(precedingEvent)	[Reaction:R-DRE-8855062] SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy [Reaction:R-DRE-351222] S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 [Reaction:R-DRE-158609] TPMT transfers CH3 from AdoMet to 6MP [Reaction:R-DRE-175987] NNMT transfers CH3 from AdoMet to PY [Reaction:R-DRE-175983] COMT transfer CH3 from AdoMet to 3,4DHBNZ
(inferredTo)	[Reaction:R-HSA-174391] MAT1A multimers transfer Ado from ATP to L-Met