Reactome | Methylation

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Methylation Show undefined attributes

authored	[InstanceEdit:158630] Jassal, B, 2005-02-03 14:13:47
created	[InstanceEdit:156583] Jassal, B, 2004-11-29 11:42:34
dbId	156581
displayName	Methylation
edited	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
eventOf	[Pathway:R-HSA-156580] Phase II - Conjugation of compounds - Homo sapiens
figure	[Figure:158547] /figures/SAM_formation.jpg
goBiologicalProcess	[GO_BiologicalProcess:258832] methylation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-174391] MAT1A multimers transfer Ado from ATP to L-Met - Homo sapiens [Reaction:R-HSA-5603114] MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met - Homo sapiens [Reaction:R-HSA-76386] CYP1A2 S-demethylates 6MMP - Homo sapiens [Reaction:R-HSA-158609] TPMT transfers CH3 from AdoMet to 6MP - Homo sapiens [Reaction:R-HSA-175976] TMT transfers CH3 from AdoMet to BME - Homo sapiens [Reaction:R-HSA-175987] NNMT transfers CH3 from AdoMet to PY - Homo sapiens [Reaction:R-HSA-175983] COMT transfer CH3 from AdoMet to 3,4DHBNZ - Homo sapiens [Reaction:R-HSA-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Homo sapiens [Reaction:R-HSA-174374] MTR transfers CH3 from MeCbl to HCYS - Homo sapiens [Reaction:R-HSA-5696220] AS3MT transfers CH3 from AdoMet to arsenite(3-) - Homo sapiens [Reaction:R-HSA-5696230] GSTO1 dimer reduces methylarsonate to methylarsonite - Homo sapiens [Reaction:R-HSA-5696213] AS3MT transfers CH3 from AdoMet to methylarsonite - Homo sapiens [Reaction:R-HSA-6800149] N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-04-07
literatureReference	[Book:76380] 9780071470513 Parkinson, A Casarett and Doull's Toxicology 5th Edn [LiteratureReference:158627] Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase [LiteratureReference:158610] S-adenosylmethionine: nothing goes to waste [LiteratureReference:158622] Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Methylation
orthologousEvent	[Pathway:R-MMU-156581] Methylation - Mus musculus [Pathway:R-RNO-156581] Methylation - Rattus norvegicus [Pathway:R-CFA-156581] Methylation - Canis familiaris [Pathway:R-BTA-156581] Methylation - Bos taurus [Pathway:R-SSC-156581] Methylation - Sus scrofa [Pathway:R-DRE-156581] Methylation - Danio rerio [Pathway:R-XTR-156581] Methylation - Xenopus tropicalis [Pathway:R-GGA-156581] Methylation - Gallus gallus [Pathway:R-DME-156581] Methylation - Drosophila melanogaster [Pathway:R-CEL-156581] Methylation - Caenorhabditis elegans [Pathway:R-DDI-156581] Methylation - Dictyostelium discoideum [Pathway:R-SPO-156581] Methylation - Schizosaccharomyces pombe [Pathway:R-SCE-156581] Methylation - Saccharomyces cerevisiae [Pathway:R-PFA-156581] Methylation - Plasmodium falciparum
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-156581
summation	[Summation:158633] Methylation is a common but minor pathway of Phase II conjug...
updateTrackers	[UpdateTracker:9788041] Update Tracker - [Pathway:156581] Methylation - v44:[updateContainedRLE] [UpdateTracker:9781089] Update Tracker - [Pathway:156581] Methylation - v61:[updateContainedRLE] [UpdateTracker:9787092] Update Tracker - [Pathway:156581] Methylation - v46:[updateContainedRLE] [UpdateTracker:9784134] Update Tracker - [Pathway:156581] Methylation - v54:[addHasEvent] [UpdateTracker:9787316] Update Tracker - [Pathway:156581] Methylation - v45:[updateContainedRLE] [UpdateTracker:9783408] Update Tracker - [Pathway:156581] Methylation - v56:[addHasEvent] [UpdateTracker:9786207] Update Tracker - [Pathway:156581] Methylation - v50:[addHasEvent, updateContainedRLE] [UpdateTracker:9792293] Update Tracker - [Pathway:156581] Methylation - v22:[updateContainedRLE] [UpdateTracker:9792158] Update Tracker - [Pathway:156581] Methylation - v23:[updateContainedRLE] [UpdateTracker:9791821] Update Tracker - [Pathway:156581] Methylation - v25:[updateContainedRLE] [UpdateTracker:9790641] Update Tracker - [Pathway:156581] Methylation - v33:[addHasEvent, updateContainedRLE] [UpdateTracker:9775232] Update Tracker - [Pathway:156581] Methylation - v80:[updateContainedRLE]

Referrals

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[Pathway:R-HSA-156580] Phase II - Conjugation of compounds

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